Save up -80% on Rilpivirine

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RX BIN: 015558
RX PCN: HT
Group ID: DDN6600
Card Holder ID: DDN6600

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2018 Price of Rilpivirine

$

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Rilpivirine volume of distribution

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What is Rilpivirine

Rilpivirine is non-nucleoside reverse transcriptase inhibitor (NNRTI) which is used for the treatment of HIV-1 infections in treatment-naive patients. It is a diarylpyrimidine, a class of molecules that resemble pyrimidine nucleotides found in DNA. Because of its flexible chemical structure, resistance of rilpivirine is less likely to develop than other NNRTI’s. FDA approved on May 20, 2011.

Rilpivirine mechanism of action

Rilpivirine is an NNRTI which binds to reverse transcriptase which results in a block in RNA and DNA- dependent DNA polymerase activities. One such activity is HIV-1 replication. Intracellular phosphorylation is not necessary for its antiviral activity. Because of the structure of rilpivirine is flexible around the aromatic rings, the molecule can have multiple conformations so that can bind to residues in the reverse transcriptase enzyme which have a lower mutation rate.

Dosage forms of Rilpivirine

FormRouteStrength
Tabletoral
Tablet, film coatedoral
Film-coated tablet page 1 of 1Oral use25 mg
Prescription Generics

false

International Brands

Complera

Synonyms

4-{[4-({4-[(E)-2-cyanovinyl]-2,6-dimethylphenyl}amino)pyrimidin-2-yl]amino}benzonitrile

Manufacturers

A S Medication Solutions

CAS number

500287-72-9

UNII

FI96A8X663

State

solid

Affected organisms

Human Immunodeficiency Virus

Indication of Rilpivirine

Treatment of HIV-1 infections in treatment-naive patients with HIV-1 RNA 100,000 copies/mL in combination with at least 2 other antiretroviral agents.

Toxicity of Rilpivirine

Oral, mouse: LD50 = 300 mg/kg; Oral, rabbit: LD50 = 3200 mg/kg; Oral, rat: LD50 = 980 mg/kg.

RX24 Drugs Disclaimer: before buying a Rilpivirine on prescription, consult your healthcare provider. Content on this page is provided for informational purposes only. Any use of this information is at your own risk.

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