Save up -80% on Rilpivirine
|Note: this is a drug discount program, not an insurance plan.|
|RX BIN: 015558||RX PCN: HT||Group ID: DDN6600||Card Holder ID: DDN6600|
|Pharmacists and Patients support.|
2019 Price of Edurant
|$1,044||30 tablets/25 mg|
|price without discount in nearest pharmacy. Price may vary.|
We offer free Rilpivirine coupons and discounts that may help you save up to 80% off the retail price in your local pharmacy. Just print your coupon! It’s ready to use and never expire. Present your manufacturer copay card in most local pharmacies to get a discount on Rilpivirine every time. What are you waiting for? Claim your prescription drug card now!
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Rilpivirine volume of distribution
The average volume of distribution was 401 liters
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Rilpivirine
Rilpivirine is non-nucleoside reverse transcriptase inhibitor (NNRTI) which is used for the treatment of HIV-1 infections in treatment-naive patients. It is a diarylpyrimidine, a class of molecules that resemble pyrimidine nucleotides found in DNA. Because of its flexible chemical structure, resistance of rilpivirine is less likely to develop than other NNRTI’s. FDA approved on May 20, 2011.
Rilpivirine mechanism of action
Rilpivirine is an NNRTI which binds to reverse transcriptase which results in a block in RNA and DNA- dependent DNA polymerase activities. One such activity is HIV-1 replication. Intracellular phosphorylation is not necessary for its antiviral activity. Because of the structure of rilpivirine is flexible around the aromatic rings, the molecule can have multiple conformations so that can bind to residues in the reverse transcriptase enzyme which have a lower mutation rate.
Dosage forms of Rilpivirine
|Tablet, film coated||oral|
|Film-coated tablet page 1 of 1||Oral use||25 mg|
A S Medication Solutions
Human Immunodeficiency Virus
Indication of Rilpivirine
Treatment of HIV-1 infections in treatment-naive patients with HIV-1 RNA 100,000 copies/mL in combination with at least 2 other antiretroviral agents.
Toxicity of Rilpivirine
Oral, mouse: LD50 = 300 mg/kg; Oral, rabbit: LD50 = 3200 mg/kg; Oral, rat: LD50 = 980 mg/kg.
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