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RX BIN: 015558
RX PCN: HT
Group ID: DDN6600
Card Holder ID: DDN6600

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2018 Price of Rimonabant

$

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Rimonabant volume of distribution

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What is Rimonabant

Rimonabant is an anorectic anti-obesity drug produced and marketed by Sanofi-Aventis. It is an inverse agonist for the cannabinoid receptor CB1. Its main avenue of effect is reduction in appetite. Rimonabant is the first selective CB1 receptor blocker to be approved for use anywhere in the world. Rimonabant is approved in 38 countries including the E.U., Mexico, and Brazil. It was rejected for approval for use in the United States. This decision was made after a U.S. advisory panel recommended the medicine not be approved because it may increase suicidal thinking and depression.

Rimonabant mechanism of action

Rimonabant is a specific CB1 cannabinoid receptor antagonist. There is considerable evidence that the endocannabinoid (endogenous cannabinoid) system plays a significant role in appetitive drive and associated behaviours. It is therefore reasonable to hypothesize that the attenuation of the activity of this system would have therapeutic benefit in treating disorders that might have a component of excess appetitive drive or over-activity of the endocannabinoid system, such as obesity, ethanol and other drug abuse, and a variety of central nervous system and other disorders.

Dosage forms of Rimonabant

FormRouteStrength
Film-coated tabletOral use20 mg
Prescription Generics

International Brands

Synonyms

Manufacturers

CAS number

168273-06-1

UNII

RML78EN3XE

State

solid

Affected organisms

Humans and other mammals

Indication of Rimonabant

For use in conjunction with diet and exercise for patients with a body mass index greater than 30 kg/msup2/sup, or patients wih a BMI greater than 27 kg/msup2/sup with associated risk factors, such as type 2 diabetes or dyslipidaemia.

Toxicity of Rimonabant

Almost twice as many people discontinued rimonabant compared with placebo because of adverse events (13.8% vs. 7.2%). These consistently involved psychiatric disorders (8.5% vs. 3.2%), including depression and anxiety. Other common side effects included insomnia, nausea, vomiting, diarrhoea and fatigue.

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