Save up -80% on Risedronate
Note: this is a drug discount program, not an insurance plan.
2018 Price of Risedronate
Actonel with calcium tablet
* price without discount in nearest pharmacy. Price may vary.
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Risedronate volume of distribution
* 13.8 L/kg
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
Risedronate mechanism of action
The action of risedronate on bone tissue is based partly on its affinity for hydroxyapatite, which is part of the mineral matrix of bone. Risedronate also targets farnesyl pyrophosphate (FPP) synthase. Nitrogen-containing bisphosphonates (such as pamidronate, alendronate, risedronate, ibandronate and zoledronate) appear to act as analogues of isoprenoid diphosphate lipids, thereby inhibiting FPP synthase, an enzyme in the mevalonate pathway. Inhibition of this enzyme in osteoclasts prevents the biosynthesis of isoprenoid lipids (FPP and GGPP) that are essential for the post-translational farnesylation and geranylgeranylation of small GTPase signalling proteins. This activity inhibits osteoclast activity and reduces bone resorption and turnover. In postmenopausal women, it reduces the elevated rate of bone turnover, leading to, on average, a net gain in bone mass.
Dosage forms of Risedronate
Acide risedroniqe Acido risedronico
Warner Chilcott (US), LLC
Humans and other mammals
Indication of Risedronate
For the treatment of Paget’s disease of the bone (osteitis deformans), postmenopausal and glucocorticoid-induced osteoporosis
Toxicity of Risedronate
Side effects include abdominal pain, anxiety, back pain, belching, bladder irritation, bone disorders and pain, bronchitis, bursitis, cataracts, chest pain, colitis, constipation, depression, diarrhea, difficulty breathing, dizziness, dry eyes, eye infection, flu-like symptoms, gas, headache, high blood pressure, infection, insomnia, itching, joint disorders and pain, leg cramps, muscle pain, muscle weakness, nausea, neck pain, nerve pain, pain, pneumonia, rash, ringing in ears, sinus problems, sore throat, stomach bleeding, stuffy or runny nose, swelling, tendon problems, tumor, ulcers, urinary tract infection, vertigo, vision problems, and weakness.
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