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Price of Rivastigmine
Exelon 1.5 mg capsule
* price without discount in nearest pharmacy. Price may vary.
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Rivastigmine volume of distribution
* 1.8 to 2.7 L/kg
What is Rivastigmine
Rivastigmine is a parasympathomimetic or cholinergic agent for the treatment of mild to moderate dementia of the Alzheimer’s type. Rivastigmine is a cholinesterase inhibitor that inhibits both butyrylcholinesterase and acetylcholinesterase.
Rivastigmine mechanism of action
Rivastigmine is a carbamate derivative that is structurally related to physostigmine, but not to donepezil and tacrine. The precise mechanism of rivastigmine has not been fully determined, but it is suggested that rivastigmine binds reversibly with and inactivates chlolinesterase (eg. acetylcholinesterase, butyrylcholinesterase), preventing the hydrolysis of acetycholine, and thus leading to an increased concentration of acetylcholine at cholinergic synapses. The anticholinesterase activity of rivastigmine is relatively specific for brain acetylcholinesterase and butyrylcholinesterase compared with those in peripheral tissues.
Dosage forms of Rivastigmine
Ena 713 Free Base
Humans and other mammals
Indication of Rivastigmine
For the treatment of mild to moderate dementia associated with Parkinson’s disease or of the Alzheimer’s type.
Toxicity of Rivastigmine
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