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RX BIN: 015558
Group ID: DDN6600
Card Holder ID: DDN6600

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2018 Price of Roflumilast


* price without discount in nearest pharmacy. Price may vary.

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Roflumilast volume of distribution

Roflumilast has a Vd of 2.9L/kg with a dose of 500mcg. Permeability of roflumilast across the blood-brain barrier appears to be poor in rat studies.

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What is Roflumilast

Roflumilast is a phosphodiesterase-4 (PDE-4) inhibitor. Due to its selective inhibition of the PDE4 isoenzyme in lung cells, roflumilast is indicated for the management of chronic obstrtuctive pulmonary disease (COPD) exacerbations. Treatment with Roflumilast is associated with an increase in psychiatric adverse reactions, including suicide and suicidal attempts.

Roflumilast mechanism of action

Roflumilast is a phosphodiesterase-4 (PDE-4) inhibitor which, due to its selective inhibition of the PDE4 isoenzyme, has potential antiinflammatory and antimodulatory effects in the pulmonary system. It is thought that the increased levels of intracellular cyclic AMP are responsible for the therapeutic actions of Roflumilast.

Dosage forms of Roflumilast

Tabletoral500 ug/1
Film-coated tabletOral use500 g
Tabletoral500 mcg
Prescription Generics


International Brands



Daliresp ROF


Astra Zeneca Pharmaceuticals Lp

CAS number






Affected organisms

Humans and other mammals

Indication of Roflumilast

Roflumilast is indicated as a treatment to reduce the risk of COPD exacerbations in patients with severe COPD associated with chronic bronchitis and a history of exacerbations. Roflumilast is not a bronchodilator and is not indicated for the relief of acute bronchospasm.

Toxicity of Roflumilast

Headache, weight loss, GI upset, insomnia, and loose stools.

RX24 Drugs Disclaimer: before buying a Roflumilast on prescription, consult your healthcare provider. Content on this page is provided for informational purposes only. Any use of this information is at your own risk.

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