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RX BIN: 015558
RX PCN: HT
Group ID: DDN6600
Card Holder ID: DDN6600

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2018 Price of Rolitetracycline

$

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Rolitetracycline volume of distribution

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What is Rolitetracycline

A pyrrolidinylmethyl tetracycline.

Rolitetracycline mechanism of action

Rolitetracycline is a semisynthetic broad-spectrum tetracycline antibiotic used especially for parenteral administration in cases requiring high concentrations or when oral administration is impractical. Rolitetracycline passively diffuses through porin channels in the bacterial membrane and reversibly binds to the 30S ribosomal subunit, preventing binding of tRNA to the mRNA-ribosome complex, and thus interfering with protein synthesis.

Dosage forms of Rolitetracycline

FormRouteStrength
Powder for solutionintra-articular; intrathecal; intraperitoneal; intrapleural; intravenous275 mg
Prescription Generics

false

International Brands

Reverin 275mg

Synonyms

N-(1-Pyrrolidinylmethyl)-tetracycline N-(Pyrrolidinomethyl)tetracycline

Manufacturers

Hoechst Canada Inc.

CAS number

751-97-3

UNII

GH9IW85221

State

solid

Affected organisms

Indication of Rolitetracycline

Rolitetracycline is a broad-spectrum antibiotic used in cases needing high concentrations or when oral administration is impractical.

Toxicity of Rolitetracycline

Symptoms of overdose include anorexia, nausea, diarrhoea, glossitis, dysphagia, enterocolitis and inflammatory lesions (with monilial overgrowth) in the anogenital region, skin reactions such as maculopapular and erythematous rashes, exfoliative dermatitis, photosensitivity, hypersensitivity reactions such as urticaria, angioneurotic oedema, anaphylaxis, anaphyl-actoid purpura, pericarditis, and exacerbation of systemic lupus erythematosus, benign intracranial hypertension in adults disappearing on discontinuation of the medicine, haematologic abnormalities such as haemolytic anaemia, thrombocytopenia, neutropenia, and eosinophilia. LD50=262 mg/kg (I.P. in rat).

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