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RX BIN: 015558
RX PCN: HT
Group ID: DDN6600
Card Holder ID: DDN6600

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2018 Price of Romiplostim

$

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Romiplostim volume of distribution

In healthy volunteers, non-linear decrease in Vd with increase IV dose of romiplostim which indicates saturation of c-Mpl receptors. Vd, 0.3 g/kg = 122 mL/kg Vd, 10 g/kg = 48.2 mL/kg

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What is Romiplostim

Romiplostim is a thrombopoiesis stimulating dimer Fc-peptide fusion protein (peptibody) to increase platelet production through activation of the thrombopoietin receptor. The peptibody molecule has two identical single-chain subunits, each one is made up of 269 amino acid residues. Each subunit consists of an IgG1 Fc carrier domain that is covalently attached to a polypeptide sequence that contains two binding domains to interact with thrombopoietin receptor c-Mpl. Each domain consists of 14 amino acids. Interestingly, romiplostim’s amino acid sequence is not similar to that of endogenous thrombopoietin. Romiplostim is produced by recombinant DNA technology in Escherichia coli. FDA approved on August 22, 2008.

Romiplostim mechanism of action

Romiplostim is a thrombopoietin receptor agonist that activates intracellular transcriptional pathways via c-Mpl to increase production of platelets. It also works similarly to thrombopoietin (TPO), an endogenous glycoprotein hormone that regulates the production of platelets in the bone marrow.

Dosage forms of Romiplostim

FormRouteStrength
Injection, powder, lyophilized, for solutionsubcutaneous250 ug/.5mL
Injection, powder, lyophilized, for solutionsubcutaneous500 ug/mL
Powder and solvent for solution for injectionSubcutaneous use250 g
Prescription Generics

false

International Brands

Nplate

Synonyms

Semaxanib Semaxinib

Manufacturers

Amgen Inc

CAS number

267639-76-9

UNII

GN5XU2DXKV

State

solid

Affected organisms

Humans and other mammals

Indication of Romiplostim

Treatment of chronic immune thrombocytopenic purpura.

Toxicity of Romiplostim

The most common adverse reactions ( 5% higher patient incidence in Nplate versus placebo) are arthralgia, dizziness, insomnia, myalgia, pain in extremity, abdominal pain, shoulder pain, dyspepsia, and paresthesia. Headache was the most commonly reported adverse reaction that did not occur at 5% higher patient incidence in Nplate versus placebo. LD50 = 980 mg/kg.

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