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2018 Price of Romiplostim
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Romiplostim volume of distribution
In healthy volunteers, non-linear decrease in Vd with increase IV dose of romiplostim which indicates saturation of c-Mpl receptors. Vd, 0.3 g/kg = 122 mL/kg Vd, 10 g/kg = 48.2 mL/kg
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Romiplostim
Romiplostim is a thrombopoiesis stimulating dimer Fc-peptide fusion protein (peptibody) to increase platelet production through activation of the thrombopoietin receptor. The peptibody molecule has two identical single-chain subunits, each one is made up of 269 amino acid residues. Each subunit consists of an IgG1 Fc carrier domain that is covalently attached to a polypeptide sequence that contains two binding domains to interact with thrombopoietin receptor c-Mpl. Each domain consists of 14 amino acids. Interestingly, romiplostim’s amino acid sequence is not similar to that of endogenous thrombopoietin. Romiplostim is produced by recombinant DNA technology in Escherichia coli. FDA approved on August 22, 2008.
Romiplostim mechanism of action
Romiplostim is a thrombopoietin receptor agonist that activates intracellular transcriptional pathways via c-Mpl to increase production of platelets. It also works similarly to thrombopoietin (TPO), an endogenous glycoprotein hormone that regulates the production of platelets in the bone marrow.
Dosage forms of Romiplostim
|Injection, powder, lyophilized, for solution||subcutaneous||250 ug/.5mL|
|Injection, powder, lyophilized, for solution||subcutaneous||500 ug/mL|
|Powder and solvent for solution for injection||Subcutaneous use||250 g|
Humans and other mammals
Indication of Romiplostim
Treatment of chronic immune thrombocytopenic purpura.
Toxicity of Romiplostim
The most common adverse reactions ( 5% higher patient incidence in Nplate versus placebo) are arthralgia, dizziness, insomnia, myalgia, pain in extremity, abdominal pain, shoulder pain, dyspepsia, and paresthesia. Headache was the most commonly reported adverse reaction that did not occur at 5% higher patient incidence in Nplate versus placebo. LD50 = 980 mg/kg.
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