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Price of Ropinirole
Requip 1 mg Tablet
* price without discount in nearest pharmacy. Price may vary.
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Ropinirole volume of distribution
* 7.5 L/kg
* 525 L
What is Ropinirole
Ropinirole is a non-ergoline dopamine agonist, manufactured by GlaxoSmithKline. It is used in the treatment of Parkinson’s disease, and is also one of two medications in the United States with an FDA-approved indication for the treatment of restless legs syndrome (the other being Pramipexole). (Wikipedia)
Ropinirole mechanism of action
Ropinirole binds the dopamine receptors D sub 3 /sub and D sub 2 /sub . Although the precise mechanism of action of ropinirole as a treatment for Parkinson’s disease is unknown, it is believed to be related to its ability to stimulate these receptors in the striatum. This conclusion is supported by electrophysiologic studies in animals that have demonstrated that ropinirole influences striatal neuronal firing rates via activation of dopamine receptors in the striatum and the substantia nigra, the site of neurons that send projections to the striatum.
Dosage forms of Ropinirole
Actavis Pharma Company
Humans and other mammals
Indication of Ropinirole
For the treatment of the signs and symptoms of idiopathic Parkinson’s disease. Also used for the treatment of restless legs syndrome.
Toxicity of Ropinirole
Symptoms of overdose include agitation, chest pain, confusion, drowsiness, facial muscle movements, grogginess, increased jerkiness of movement, symptoms of low blood pressure (dizziness, light-headedness)upon standing, nausea, and vomiting.
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