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RX BIN: 015558RX PCN: HTGroup ID: DDN6600Card Holder ID: DDN6600
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2019 Price of Naropin

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Ropivacaine volume of distribution

Total ropivacaine volume of distribution per kg body weight increases from 0.9 and 1.0 L/kg for the newborn and the 1-month neonate to 1.7-2.6 L/kg beyond the age of 6 months. The terminal half-life of ropivacaine is longer, 6 to 5 h in the newborn and the 1- month neonate compared to about 3 h in older children.

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What is Ropivacaine

Ropivacaine is a local anaesthetic drug belonging to the amino amide group. The name ropivacaine refers to both the racemate and the marketed S-enantiomer. Ropivacaine hydrochloride is commonly marketed by AstraZeneca under the trade name Naropin. (Wikipedia)

Ropivacaine mechanism of action

Local anesthetics such as Ropivacaine block the generation and the conduction of nerve impulses, presumably by increasing the threshold for electrical excitation in the nerve, by slowing the propagation of the nerve impulse, and by reducing the rate of rise of the action potential. Specifically, they block the sodium-channel and decrease chances of depolarization and consequent action potentials. In general, the progression of anesthesia is related to the diameter, myelination and conduction velocity of affected nerve fibers.

Dosage forms of Ropivacaine

Injection, solutionepidural; infiltration2 mg/mL
Solutionepidural10 mg
Solutionblock/infiltration; epidural2 mg

Prescription Generics


International Brands



(S)-()-1-propyl-2′,6′-pipecoloxylidide (S)-ropivacaine


Fresenius Kabi USA, LLC

CAS number






Affected organisms

Humans and other mammals

Indication of Ropivacaine

Used in obstetric anesthesia and regional anesthesia for surgery.

Toxicity of Ropivacaine

Systemic exposure to excessive quantities of ropivacaine mainly result in central nervous system (CNS) and cardiovascular effects CNS effects usually occur at lower blood plasma concentrations and additional cardiovascular effects present at higher concentrations, though cardiovascular collapse may also occur with low concentrations. CNS effects may include CNS excitation (nervousness, tingling around the mouth, tinnitus, tremor, dizziness, blurred vision, seizures) followed by depression (drowsiness, loss of consciousness, respiratory depression and apnea). Cardiovascular effects include hypotension, bradycardia, arrhythmias, and/or cardiac arrest some of which may be due to hypoxemia secondary to respiratory depression.

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