Save up -80% on Rosiglitazone

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RX BIN: 015558
RX PCN: HT
Group ID: DDN6600
Card Holder ID: DDN6600

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2018 Price of Rosiglitazone

Avandia 2 mg tablet

$3.22

tablet

* price without discount in nearest pharmacy. Price may vary.

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Rosiglitazone volume of distribution

* 17.6 L (oral volume of distribution Vss/F) * 13.5 L (population mean, pediatric patients)

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What is Rosiglitazone

Rosiglitazone is an anti-diabetic drug in the thiazolidinedione class of drugs. It is marketed by the pharmaceutical company GlaxoSmithKline as a stand-alone drug (Avandia) and in combination with metformin (Avandamet) or with glimepiride (Avandaryl). Like other thiazolidinediones, the mechanism of action of rosiglitazone is by activation of the intracellular receptor class of the peroxisome proliferator-activated receptors (PPARs), specifically PPAR.. Rosiglitazone is a selective ligand of PPAR., and has no PPAR.-binding action. Apart from its effect on insulin resistance, it appears to have an anti-inflammatory effect: nuclear factor kappa-B (NF.B) levels fall and inhibitor (I.B) levels increase in patients on rosiglitazone. Recent research has suggested that rosiglitazone may also be of benefit to a subset of patients with Alzheimer’s disease not expressing the ApoE4 allele. This is the subject of a clinical trial currently underway.

Rosiglitazone mechanism of action

Rosiglitazone acts as a highly selective and potent agonist at peroxisome proliferator activated receptors (PPAR) in target tissues for insulin action such as adipose tissue, skeletal muscle, and liver. Activation of PPAR-gamma receptors regulates the transcription of insulin-responsive genes involved in the control of glucose production, transport, and utilization. In this way, rosiglitazone enhances tissue sensitivity to insulin.

Dosage forms of Rosiglitazone

FormRouteStrength
Tabletoral2.0 mg
Tabletoral4.0 mg
Tabletoral8.0 mg
Prescription Generics

true

International Brands

Apo-rosiglitazone

Synonyms

()-5-(p-(2-(methyl-2-pyridylamino)ethoxy)benzyl)-2,4-thiazolidinedione (RS)-5-{4-(2-(Methyl-2-pyridylamino)ethoxy)benzyl}-2,4-thiazolidinedion

Manufacturers

Apotex Inc

CAS number

122320-73-4

UNII

05V02F2KDG

State

solid

Affected organisms

Humans and other mammals

Indication of Rosiglitazone

Rosiglitazone is indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus.

Toxicity of Rosiglitazone

Side effects include fluid retention, congestive heart failure (CHF), liver disease

RX24 Drugs Disclaimer: before buying a Rosiglitazone on prescription, consult your healthcare provider. Content on this page is provided for informational purposes only. Any use of this information is at your own risk.

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