Save up -80% on Rosiglitazone
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Price of Rosiglitazone
Avandia 2 mg tablet
* price without discount in nearest pharmacy. Price may vary.
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Rosiglitazone volume of distribution
* 17.6 L (oral volume of distribution Vss/F)
* 13.5 L (population mean, pediatric patients)
What is Rosiglitazone
Rosiglitazone is an anti-diabetic drug in the thiazolidinedione class of drugs. It is marketed by the pharmaceutical company GlaxoSmithKline as a stand-alone drug (Avandia) and in combination with metformin (Avandamet) or with glimepiride (Avandaryl). Like other thiazolidinediones, the mechanism of action of rosiglitazone is by activation of the intracellular receptor class of the peroxisome proliferator-activated receptors (PPARs), specifically PPAR.. Rosiglitazone is a selective ligand of PPAR., and has no PPAR.-binding action. Apart from its effect on insulin resistance, it appears to have an anti-inflammatory effect: nuclear factor kappa-B (NF.B) levels fall and inhibitor (I.B) levels increase in patients on rosiglitazone. Recent research has suggested that rosiglitazone may also be of benefit to a subset of patients with Alzheimer’s disease not expressing the ApoE4 allele. This is the subject of a clinical trial currently underway.
Rosiglitazone mechanism of action
Rosiglitazone acts as a highly selective and potent agonist at peroxisome proliferator activated receptors (PPAR) in target tissues for insulin action such as adipose tissue, skeletal muscle, and liver. Activation of PPAR-gamma receptors regulates the transcription of insulin-responsive genes involved in the control of glucose production, transport, and utilization. In this way, rosiglitazone enhances tissue sensitivity to insulin.
Dosage forms of Rosiglitazone
Humans and other mammals
Indication of Rosiglitazone
Rosiglitazone is indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus.
Toxicity of Rosiglitazone
Side effects include fluid retention, congestive heart failure (CHF), liver disease
Disclaimer: before buying a Rosiglitazone on prescription, consult your health care provider. Content on this page is provided for informational purposes only. Any use of this information is at your own risk.