Save up -80% on Rosuvastatin
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2018 Price of Rosuvastatin
Crestor 5 mg Tablet
* price without discount in nearest pharmacy. Price may vary.
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Rosuvastatin volume of distribution
|Act Rosuvastatin||Tablet||10 mg||Oral||Actavis Pharma Company|
|Crestor||Tablet, film coated||5 mg/1||Oral||Rebel Distributors|
|M-rosuvastatin||Tablet||20 mg||Oral||Mantra Pharma Inc|
|Q-rosuvastatin||Tablet||10.0 mg||Oral||Qd Pharmaceuticals Ulc|
|Rosuvastatin||Tablet||20 mg||Oral||Cobalt Laboratories|
|Sandoz Rosuvastatin||Tablet||40 mg||Oral||Sandoz Canada Incorporated|
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Rosuvastatin
Rosuvastatin is an antilipemic agent that competitively inhibits hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase. HMG-CoA reducuase catalyzes the conversion of HMG-CoA to mevalonic acid, the rate-limiting step in cholesterol biosynthesis. Rosuvastatin belongs to a class of medications called statins and is used to reduce plasma cholesterol levels and prevent cardiovascular disease.
Rosuvastatin mechanism of action
Rosuvastatin is a competitive inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early rate-limiting step in cholesterol biosynthesis. Rosuvastatin acts primarily in the liver. Decreased hepatic cholesterol concentrations stimulate the upregulation of hepatic low density lipoprotein (LDL) receptors which increases hepatic uptake of LDL. Rosuvastatin also inhibits hepatic synthesis of very low density lipoprotein (VLDL). The overall effect is a decrease in plasma LDL and VLDL. In vitro and in vivo animal studies also demonstrate that rosuvastatin exerts vasculoprotective effects independent of its lipid-lowering properties. Rosuvastatin exerts an anti-inflammatory effect on rat mesenteric microvascular endothelium by attenuating leukocyte rolling, adherence and transmigration (PMID: 11375257). The drug also modulates nitric oxide synthase (NOS) expression and reduces ischemic-reperfusion injuries in rat hearts (PMID: 15914111). Rosuvastatin increases the bioavailability of nitric oxide (PMID: 11375257, 12031849, 15914111) by upregulating NOS (PMID: 12354446) and by increasing the stability of NOS through post-transcriptional polyadenylation (PMID: 17916773). It is unclear as to how rosuvastatin brings about these effects though they may be due to decreased concentrations of mevalonic acid.
Dosage forms of Rosuvastatin
Ach-rosuvastatin, Auro-rosuvastatin, Bio-rosuvastatin, Dom-rosuvastatin, Ipg-rosuvastatin, Jamp-rosuvastatin, Mar-rosuvastatin, Med-rosuvastatin, Mint-rosuvastatin, Mylan-rosuvastatin, Novo-rosuvastatin, Ntp-rosuvastatin, PMS-rosuvastatin, Priva-rosuvastatin, Ran-rosuvastatin, Riva-rosuvastatin, Rosuvastatin, Rosuvastatin Calcium, Teva-rosuvastatin
Astende, Cirantan, Cresadex, Provisacor, Razel, Rosedex, Rosimol, Rosumed, Rosustatin, Rosuvas, Rosuvast, Rosvel, Rovartal, Simestat, Sinlip, Visacor, Vivacor
Act Rosuvastatin, Crestor Tablet, M-rosuvastatin, Q-rosuvastatin, Rosuvastatin, Sandoz Rosuvastatin
AS Medication Solutions, Actavis Pharma Company, Aphena Pharma Solutions Tennessee, Astra Zeneca, Avera Mc Kennan Hospital, Bryant ranch prepack, Cardinal Health, Carilion Materials Management, Cobalt Laboratories, H.J. Harkins Company, Lake Erie Medical&Surgical, Mantra Pharma Inc, Mesource Pharmaceuticals, Pd Rx Pharmaceuticals, Physicians Total Care, Pro Doc Limitee, Qd Pharmaceuticals Ulc, Ranbaxy Inc, Rebel Distributors, Remedy Repack, Sandoz Canada Incorporated, Sanis Health Inc, Sivem Pharmaceuticals Ulc
Humans and other mammals
Indication of Rosuvastatin
Used as an adjunct to dietary therapy to treat primary hyperlipidemia (heterozygous familial and nonfamilial), mixed dyslipidemia and hypertriglyceridemia. Also indicated for homozygous familial hypercholesterolemia as an adjunct to other lipid-lowering therapies or when other such therapies are not available. Furthermore, it is used to slow the progression of atherosclerosis and for primary prevention of cardiovascular disease.
Toxicity of Rosuvastatin
Generally well-tolerated. Side effects may include myalgia, constipation, asthenia, abdominal pain, and nausea. Other possible side effects include myotoxicity (myopathy, myositis, rhabdomyolysis) and hepatotoxicity. To avoid toxicity in Asian patients, lower doses should be considered. Pharmacokinetic studies show an approximately two-fold increase in peak plasma concentration and AUC in Asian patients (Philippino, Chinese, Japanese, Korean, Vietnamese, or Asian-Indian descent) compared to Caucasians patients.
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