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RX BIN: 015558RX PCN: HTGroup ID: DDN6600Card Holder ID: DDN6600
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2019 Price of Crestor

$11.4530 tablets/10 mg
price without discount in nearest pharmacy. Price may vary.

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Rosuvastatin volume of distribution

NameDosageStrengthRouteLabeller
Act RosuvastatinTablet10 mgOralActavis Pharma Company
CrestorTablet, film coated5 mg/1OralRebel Distributors
M-rosuvastatinTablet20 mgOralMantra Pharma Inc
Q-rosuvastatinTablet10.0 mgOralQd Pharmaceuticals Ulc
RosuvastatinTablet20 mgOralCobalt Laboratories
Sandoz RosuvastatinTablet40 mgOralSandoz Canada Incorporated
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2018 Statistics

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Discount Cards 16,000+

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Clients Benefit 29%

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Total savings $4,735,080

What is Rosuvastatin

Rosuvastatin is an antilipemic agent that competitively inhibits hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase. HMG-CoA reducuase catalyzes the conversion of HMG-CoA to mevalonic acid, the rate-limiting step in cholesterol biosynthesis. Rosuvastatin belongs to a class of medications called statins and is used to reduce plasma cholesterol levels and prevent cardiovascular disease.

Rosuvastatin mechanism of action

Rosuvastatin is a competitive inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonate, an early rate-limiting step in cholesterol biosynthesis. Rosuvastatin acts primarily in the liver. Decreased hepatic cholesterol concentrations stimulate the upregulation of hepatic low density lipoprotein (LDL) receptors which increases hepatic uptake of LDL. Rosuvastatin also inhibits hepatic synthesis of very low density lipoprotein (VLDL). The overall effect is a decrease in plasma LDL and VLDL. In vitro and in vivo animal studies also demonstrate that rosuvastatin exerts vasculoprotective effects independent of its lipid-lowering properties. Rosuvastatin exerts an anti-inflammatory effect on rat mesenteric microvascular endothelium by attenuating leukocyte rolling, adherence and transmigration (PMID: 11375257). The drug also modulates nitric oxide synthase (NOS) expression and reduces ischemic-reperfusion injuries in rat hearts (PMID: 15914111). Rosuvastatin increases the bioavailability of nitric oxide (PMID: 11375257, 12031849, 15914111) by upregulating NOS (PMID: 12354446) and by increasing the stability of NOS through post-transcriptional polyadenylation (PMID: 17916773). It is unclear as to how rosuvastatin brings about these effects though they may be due to decreased concentrations of mevalonic acid.

Dosage forms of Rosuvastatin

DrugDosageQuantityPrice
Crestor5mg90 Tablet$56.60
Crestor10mg90 Tablet$48.20
Crestor20mg84 Tablet$33.25
Crestor40mg84 Tablet$94.50
Rosuvastatin5mg84 Tablet$24.00
Rosuvastatin10mg84 Tablet$47.00
Rosuvastatin20mg84 Tablet$32.90
Rosuvastatin40mg84 Tablet$33.55

Prescription Generics

Ach-rosuvastatin, Auro-rosuvastatin, Bio-rosuvastatin, Dom-rosuvastatin, Ipg-rosuvastatin, Jamp-rosuvastatin, Mar-rosuvastatin, Med-rosuvastatin, Mint-rosuvastatin, Mylan-rosuvastatin, Novo-rosuvastatin, Ntp-rosuvastatin, PMS-rosuvastatin, Priva-rosuvastatin, Ran-rosuvastatin, Riva-rosuvastatin, Rosuvastatin, Rosuvastatin Calcium, Teva-rosuvastatin

International Brands

Astende, Cirantan, Cresadex, Provisacor, Razel, Rosedex, Rosimol, Rosumed, Rosustatin, Rosuvas, Rosuvast, Rosvel, Rovartal, Simestat, Sinlip, Visacor, Vivacor

Synonyms

Act Rosuvastatin, Crestor Tablet, M-rosuvastatin, Q-rosuvastatin, Rosuvastatin, Sandoz Rosuvastatin

Manufacturers

AS Medication Solutions, Actavis Pharma Company, Aphena Pharma Solutions Tennessee, Astra Zeneca, Avera Mc Kennan Hospital, Bryant ranch prepack, Cardinal Health, Carilion Materials Management, Cobalt Laboratories, H.J. Harkins Company, Lake Erie Medical&Surgical, Mantra Pharma Inc, Mesource Pharmaceuticals, Pd Rx Pharmaceuticals, Physicians Total Care, Pro Doc Limitee, Qd Pharmaceuticals Ulc, Ranbaxy Inc, Rebel Distributors, Remedy Repack, Sandoz Canada Incorporated, Sanis Health Inc, Sivem Pharmaceuticals Ulc

CAS number

287714-41-4

UNII

413KH5ZJ73

State

solid

Affected organisms

Humans and other mammals

Indication of Rosuvastatin

Used as an adjunct to dietary therapy to treat primary hyperlipidemia (heterozygous familial and nonfamilial), mixed dyslipidemia and hypertriglyceridemia. Also indicated for homozygous familial hypercholesterolemia as an adjunct to other lipid-lowering therapies or when other such therapies are not available. Furthermore, it is used to slow the progression of atherosclerosis and for primary prevention of cardiovascular disease.

Toxicity of Rosuvastatin

Generally well-tolerated. Side effects may include myalgia, constipation, asthenia, abdominal pain, and nausea. Other possible side effects include myotoxicity (myopathy, myositis, rhabdomyolysis) and hepatotoxicity. To avoid toxicity in Asian patients, lower doses should be considered. Pharmacokinetic studies show an approximately two-fold increase in peak plasma concentration and AUC in Asian patients (Philippino, Chinese, Japanese, Korean, Vietnamese, or Asian-Indian descent) compared to Caucasians patients.

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What is Crestor?

Crestor is effective in adult patients with hypercholesterolemia with or without hypertriglyceridemia; regardless of race, gender or age, incl. in patients with diabetes and familial hypercholesterolemia. In 80% of patients with hypercholesterolemia IIa and IIb type according to Fredrickson (the average initial concentration of LDL-C is about 4.8 mmol / l) while receiving the drug at a dose of 10 mg, the concentration of LDL-C makes up values ​​less than 3 mmol / l.

Patients with heterozygous familial hypercholesterolemia receiving Crestor at a dose of 20-80 mg show a positive dynamics of lipid profile (study with 435 patients). After titration to a daily dose of 40 mg (12 weeks of therapy), a decrease in the concentration of LDL-C by 53% is noted. 33% of patients achieved a ChL-LDL concentration of less than 3 mmol / l.

In patients with homozygous familial hypercholesterolemia, taking Crestor at a dose of 20 mg and 40 mg, the average decrease in the concentration of LDL-C is 22%.