Save up -80% on Ruxolitinib
|Note: this is a drug discount program, not an insurance plan.|
|RX BIN: 015558||RX PCN: HT||Group ID: DDN6600||Card Holder ID: DDN6600|
|Pharmacists and Patients support.|
2019 Price of Jakafi
|$12,830||60 tablets/10 mg|
|price without discount in nearest pharmacy. Price may vary.|
We offer free Ruxolitinib coupons and discounts that may help you save up to 80% off the retail price in your local pharmacy. Just print your coupon! It’s ready to use and never expire. Present your manufacturer copay card in most local pharmacies to get a discount on Ruxolitinib every time. What are you waiting for? Claim your prescription drug card now!
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Ruxolitinib volume of distribution
Terminal phase volume of distribution, 15 mg, healthy subject = 76.6 L.
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Ruxolitinib
Ruxolitinib is a janus-associated kinase inhibitor indicated to treat bone marrow cancer, specifically intermediate or high-risk myelofibrosis. FDA approved on November 16, 2011.
Ruxolitinib mechanism of action
Ruxolitinib is a kinase inhibitor that is selective for the Janus Associated Kinases (JAK) 1 and 2. These kinases are responsible for the mediation of cytokine and growth factor signalling which in turn effect immune function and hematopoiesis. The signalling process involves signal transducers and transcription activators (STAT) which modulate gene expression. Patients with myelofibrosis have abnormal JAK1 and JAK2 activity thus ruxolitinib works to regulate this.
Dosage forms of Ruxolitinib
Humans and other mammals
Indication of Ruxolitinib
Treatment of intermediate or high-risk myelofibrosis, including primary myelofibrosis, post-polycythemia vera (post-PV) myelofibrosis and post-essential thrombocythemia (post-ET) myelofibrosis.[Lexicomp]Myeolofibrosis is the proliferation of abnormal bone marrow stem cells which cause fibrosis (the excessive formation of connective tissue).
Toxicity of Ruxolitinib
Thrombocytopenia was the dose-limiting toxicity.
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