Save up -80% on Ruxolitinib
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2018 Price of Ruxolitinib
* price without discount in nearest pharmacy. Price may vary.
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Ruxolitinib volume of distribution
Terminal phase volume of distribution, 15 mg, healthy subject = 76.6 L.
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
Ruxolitinib mechanism of action
Ruxolitinib is a kinase inhibitor that is selective for the Janus Associated Kinases (JAK) 1 and 2. These kinases are responsible for the mediation of cytokine and growth factor signalling which in turn effect immune function and hematopoiesis. The signalling process involves signal transducers and transcription activators (STAT) which modulate gene expression. Patients with myelofibrosis have abnormal JAK1 and JAK2 activity thus ruxolitinib works to regulate this.
Dosage forms of Ruxolitinib
Humans and other mammals
Indication of Ruxolitinib
Treatment of intermediate or high-risk myelofibrosis, including primary myelofibrosis, post-polycythemia vera (post-PV) myelofibrosis and post-essential thrombocythemia (post-ET) myelofibrosis.[Lexicomp]Myeolofibrosis is the proliferation of abnormal bone marrow stem cells which cause fibrosis (the excessive formation of connective tissue).
Toxicity of Ruxolitinib
Thrombocytopenia was the dose-limiting toxicity.
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