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RX BIN: 015558
RX PCN: HT
Group ID: DDN6600
Card Holder ID: DDN6600

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2018 Price of Salicylic acid

Salicylic acid 6% gel

$1.14

g

* price without discount in nearest pharmacy. Price may vary.

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Salicylic acid volume of distribution

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What is Salicylic acid

A compound obtained from the bark of the white willow and wintergreen leaves, and also prepared synthetically. It has bacteriostatic, fungicidal, and keratolytic actions. Its salts, the salicylates, are used as analgesics.

Salicylic acid mechanism of action

Salicylic acid directly and irreversibly inhibits the activity of both types of cyclo-oxygenases (COX-1 and COX-2) to decrease the formation of precursors of prostaglandins and thromboxanes from arachidonic acid. Salicylate may competitively inhibit prostaglandin formation. Salicylate’s antirheumatic (nonsteroidal anti-inflammatory) actions are a result of its analgesic and anti-inflammatory mechanisms. Salicylic acid is a key ingredient in many skin-care products for the treatment of acne, psoriasis, calluses, corns, keratosis pilaris, and warts. It works by causing the cells of the epidermis to slough off more readily, preventing pores from clogging up, and allowing room for new cell growth. Because of its effect on skin cells, salicylic acid is used in several shampoos used to treat dandruff. Salicylic acid is also used as an active ingredient in gels which remove verrucas (plantar warts). Salicylic acid inhibits the oxidation of uridine-5-diphosphoglucose (UDPG) competitively with nicotinamide adenosine dinucleotide (NAD) and noncompetitively with UDPG. It also competitively inhibits the transferring of glucuronyl group of uridine-5-phosphoglucuronic acid (UDPGA) to the phenolic acceptor. The wound-healing retardation action of salicylates is probably due mainly to its inhibitory action on mucopolysaccharide synthesis.

Dosage forms of Salicylic acid

FormRouteStrength
Geltopical.6 g/120mL
Creamtopical.001 mg/10mL
Liquidtopical.1 mg/100mL
Prescription Generics

false

International Brands

24 Hour Pimple Punisher

Synonyms

2-Carboxyphenol 2-Hydroxybenzoic acid

Manufacturers

KATE SOMERVILLE SKINCARE, LLC

CAS number

69-72-7

UNII

O414PZ4LPZ

State

solid

Affected organisms

Humans and other mammals

Indication of Salicylic acid

Key additive in many skin-care products for the treatment of acne, psoriasis, callouses, corns, keratosis pilaris and warts.

Toxicity of Salicylic acid

Oral rat LD50: 891 mg/kg. Inhalation rat LC50: 900 mg/m3/1hr. Irritation: skin rabbit: 500 mg/24H mild. Eye rabbit: 100 mg severe. Investigated a mutagen and reproductive effector.

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