Save up -80% on Sargramostim
|Note: this is a drug discount program, not an insurance plan.|
|RX BIN: 015558||RX PCN: HT||Group ID: DDN6600||Card Holder ID: DDN6600|
|Pharmacists and Patients support.|
2019 Price of Leukine
|price without discount in nearest pharmacy. Price may vary.|
We offer free Leukine coupons and discounts that may help you save up to 80% off the retail price in your local pharmacy. Just print your coupon! It’s ready to use and never expire. Present your manufacturer copay card in most local pharmacies to get a discount on Sargramostim every time. What are you waiting for? Claim your prescription drug card now!
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Sargramostim volume of distribution
Sargramostim is administered intravenously (IV) or subcutaneously. Following IV administration, the observed volume of distribution was 96.8%. In healthy volunteers, the mean terminal elimination half-life values were 3.84 and 1.4 hours and the mean clearance values were 17.2 and 23 L/hour following sargramostim 500 mcg IV (over 2 hours) and sargramostim as a subcutaneous injection, respectively. Sargramostim appears to be metabolized to small peptides and amino acids.
|Injection, powder, for solution||intravenous; subcutaneous||250 ug/mL|
|Liquid||intravenous; subcutaneous||500 ug/mL|
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Sargramostim
Sargramostim is a human recombinant granulocyte macrophage colony-stimulating factor (GM-CSF) expressed in yeast. It is a glycoprotein that is 127 residues. Substitution of Leu23 leads to a difference from native protein.
Sargramostim mechanism of action
Sargramostim binds to the Granulocyte-macrophage colony stimulating factor receptor (GM-CSF-R-alpha or CSF2R) which stimulates a JAK2 STAT1/STAT3 signal transduction pathway. This leads to the production of hemopoietic cells and neutrophils
Dosage forms of Sargramostim
Sanofi Aventis U.S. Llc
Humans and other mammals
Indication of Sargramostim
For the treatment of cancer and bone marrow transplant
Toxicity of Sargramostim
Among patients with unresectable stage III or IV melanoma, treatment with sargramostim plus ipilimumab, compared to ipilimumab alone, resulted in longer overall survival and lower toxicity, but no difference in progression free survival. These findings require confirmation in larger sample sizes and longer follow up.
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