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RX BIN: 015558
RX PCN: HT
Group ID: DDN6600
Card Holder ID: DDN6600

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2018 Price of Saxagliptin

$

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Saxagliptin volume of distribution

151 L

About RX24Drugs

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What is Saxagliptin

Saxagliptin (rINN) is an orally active hypoglycemic (anti-diabetic drug) of the new dipeptidyl peptidase-4 (DPP-4) inhibitor class of drugs. FDA approved on July 31, 2009.

Saxagliptin mechanism of action

Saxagliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor antidiabetic for the treatment of type 2 diabetes. DPP-4 inhibitors are a class of compounds that work by affecting the action of natural hormones in the body called incretins. Incretins decrease blood sugar by increasing consumption of sugar by the body, mainly through increasing insulin production in the pancreas, and by reducing production of sugar by the liver.[Bristol-Myers Squibb Press Release]DPP-4 is a membrane associated peptidase which is found in many tissues, lymphocytes and plasma. DPP-4 has two main mechanisms of action, an enzymatic function and another mechanism where DPP-4 binds adenosine deaminase, which conveys intracellular signals via dimerization when activated. Saxagliptin forms a reversible, histidine-assisted covalent bond between its nitrile group and the S630 hydroxyl oxygen on DPP-4. The inhibition of DPP-4 increases levels active of glucagon like peptide 1 (GLP-1), which inhibits glucagon production from pancreatic alpha cells and increases production of insulin from pancreatic beta cells.

Dosage forms of Saxagliptin

FormRouteStrength
Tablet, film coated, extended releaseoral
Tabletoral
Film-coated tabletOral use2.5 mg
Prescription Generics

false

International Brands

Kombiglyze XR

Synonyms

(1S,3S,5S)-2-((2S)-Amino(3-hydroxytricyclo(3.3.1.13,7)dec-1-yl)acetyl)-2-azabicyclo(3.1.0)hexane-3-carbonitrile BMS 477118

Manufacturers

Astra Zeneca Pharmaceuticals Lp

CAS number

361442-04-8

UNII

8I7IO46IVQ

State

solid

Affected organisms

Indication of Saxagliptin

Treatment of type 2 diabetes mellitus to improve glycemic control in combination with other agents or as monotherapy.

Toxicity of Saxagliptin

Adverse reactions reported in 5% of patients treated with saxagliptin and more commonly than in patients treated with placebo are: upper respiratory tract infection, urinary tract infection, and headache.

RX24 Drugs Disclaimer: before buying a Saxagliptin on prescription, consult your healthcare provider. Content on this page is provided for informational purposes only. Any use of this information is at your own risk.

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