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RX BIN: 015558RX PCN: HTGroup ID: DDN6600Card Holder ID: DDN6600
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2019 Price of Onglyza

$406.3030 tablets/5 mg
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We offer free Onglyza coupons and discounts that may help you save up to 80% off the retail price in your local pharmacy. Just print your coupon! It’s ready to use and never expire. Present your manufacturer copay card in most local pharmacies to get a discount on Saxagliptin every time. What are you waiting for? Claim your prescription drug card now!

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Saxagliptin volume of distribution

Saxagliptin was rapidly absorbed and had good bioavailability (50-75%) in the species tested. The plasma clearance of saxagliptin was higher in rats (115 ml/min/kg) than in dogs (9.3 ml/min/kg) and monkeys (14.5 ml/min/kg) and was predicted to be low to moderate in humans.

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2018 Statistics

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Discount Cards 16,000+

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Clients Benefit 29%

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Total savings $4,735,080

What is Saxagliptin

Saxagliptin (rINN) is an orally active hypoglycemic (anti-diabetic drug) of the new dipeptidyl peptidase-4 (DPP-4) inhibitor class of drugs. FDA approved on July 31, 2009.

Saxagliptin mechanism of action

Saxagliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor antidiabetic for the treatment of type 2 diabetes. DPP-4 inhibitors are a class of compounds that work by affecting the action of natural hormones in the body called incretins. Incretins decrease blood sugar by increasing consumption of sugar by the body, mainly through increasing insulin production in the pancreas, and by reducing production of sugar by the liver.[Bristol-Myers Squibb Press Release]DPP-4 is a membrane associated peptidase which is found in many tissues, lymphocytes and plasma. DPP-4 has two main mechanisms of action, an enzymatic function and another mechanism where DPP-4 binds adenosine deaminase, which conveys intracellular signals via dimerization when activated. Saxagliptin forms a reversible, histidine-assisted covalent bond between its nitrile group and the S630 hydroxyl oxygen on DPP-4. The inhibition of DPP-4 increases levels active of glucagon like peptide 1 (GLP-1), which inhibits glucagon production from pancreatic alpha cells and increases production of insulin from pancreatic beta cells.

Dosage forms of Saxagliptin

FormRouteStrength
Tablet, film coated, extended releaseoral
Tabletoral
Film-coated tabletOral use2.5 mg

Prescription Generics

false

International Brands

Kombiglyze XR

Synonyms

(1S,3S,5S)-2-((2S)-Amino(3-hydroxytricyclo(3.3.1.13,7)dec-1-yl)acetyl)-2-azabicyclo(3.1.0)hexane-3-carbonitrile BMS 477118

Manufacturers

Astra Zeneca Pharmaceuticals Lp

CAS number

361442-04-8

UNII

8I7IO46IVQ

State

solid

Affected organisms

Indication of Saxagliptin

Treatment of type 2 diabetes mellitus to improve glycemic control in combination with other agents or as monotherapy.

Toxicity of Saxagliptin

Adverse reactions reported in 5% of patients treated with saxagliptin and more commonly than in patients treated with placebo are: upper respiratory tract infection, urinary tract infection, and headache.

RX24 Drugs Disclaimer: consult your healthcare provider before buying a Saxagliptin on prescription or using an RX manufacturer savings coupon. Content on this page is provided for informational purposes only. Any use of this information is at your own risk.

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What is Onglyza?

Onglyza is an oral diabetes medicine that helps control blood sugar levels. It works by regulating the levels of insulin that the body produces after eating.

Onglyza is for people with type 2 diabetes. It is sometimes used in combination with other drugs to treat diabetes, but not to treat type 1 diabetes.

You should not use Onglyza if you are in a state of diabetic ketoacidosis (consult your doctor for insulin treatment). It is not intended to treat type 1 diabetes. Before taking Onglyza, tell your doctor if you have kidney disease or if you are on dialysis.

Onglyza is only part of a complete treatment program, which also includes diet, exercise, weight control, and possibly other medications. It is important to use this medicine regularly to get the most benefit. Get a prescription filled before you run out of medicine.