Save up -80% on Saxagliptin
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2018 Price of Saxagliptin
* price without discount in nearest pharmacy. Price may vary.
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Saxagliptin volume of distribution
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Saxagliptin
Saxagliptin (rINN) is an orally active hypoglycemic (anti-diabetic drug) of the new dipeptidyl peptidase-4 (DPP-4) inhibitor class of drugs. FDA approved on July 31, 2009.
Saxagliptin mechanism of action
Saxagliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor antidiabetic for the treatment of type 2 diabetes. DPP-4 inhibitors are a class of compounds that work by affecting the action of natural hormones in the body called incretins. Incretins decrease blood sugar by increasing consumption of sugar by the body, mainly through increasing insulin production in the pancreas, and by reducing production of sugar by the liver.[Bristol-Myers Squibb Press Release]DPP-4 is a membrane associated peptidase which is found in many tissues, lymphocytes and plasma. DPP-4 has two main mechanisms of action, an enzymatic function and another mechanism where DPP-4 binds adenosine deaminase, which conveys intracellular signals via dimerization when activated. Saxagliptin forms a reversible, histidine-assisted covalent bond between its nitrile group and the S630 hydroxyl oxygen on DPP-4. The inhibition of DPP-4 increases levels active of glucagon like peptide 1 (GLP-1), which inhibits glucagon production from pancreatic alpha cells and increases production of insulin from pancreatic beta cells.
Dosage forms of Saxagliptin
|Tablet, film coated, extended release||oral|
|Film-coated tablet||Oral use||2.5 mg|
(1S,3S,5S)-2-((2S)-Amino(3-hydroxytricyclo(18.104.22.168,7)dec-1-yl)acetyl)-2-azabicyclo(3.1.0)hexane-3-carbonitrile BMS 477118
Astra Zeneca Pharmaceuticals Lp
Indication of Saxagliptin
Treatment of type 2 diabetes mellitus to improve glycemic control in combination with other agents or as monotherapy.
Toxicity of Saxagliptin
Adverse reactions reported in 5% of patients treated with saxagliptin and more commonly than in patients treated with placebo are: upper respiratory tract infection, urinary tract infection, and headache.
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