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RX BIN: 015558RX PCN: HTGroup ID: DDN6600Card Holder ID: DDN6600
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2019 Price of Onglyza

$406.3030 tablets/5 mg
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Saxagliptin volume of distribution

Saxagliptin was rapidly absorbed and had good bioavailability (50-75%) in the species tested. The plasma clearance of saxagliptin was higher in rats (115 ml/min/kg) than in dogs (9.3 ml/min/kg) and monkeys (14.5 ml/min/kg) and was predicted to be low to moderate in humans.

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What is Saxagliptin

Saxagliptin (rINN) is an orally active hypoglycemic (anti-diabetic drug) of the new dipeptidyl peptidase-4 (DPP-4) inhibitor class of drugs. FDA approved on July 31, 2009.

Saxagliptin mechanism of action

Saxagliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor antidiabetic for the treatment of type 2 diabetes. DPP-4 inhibitors are a class of compounds that work by affecting the action of natural hormones in the body called incretins. Incretins decrease blood sugar by increasing consumption of sugar by the body, mainly through increasing insulin production in the pancreas, and by reducing production of sugar by the liver.[Bristol-Myers Squibb Press Release]DPP-4 is a membrane associated peptidase which is found in many tissues, lymphocytes and plasma. DPP-4 has two main mechanisms of action, an enzymatic function and another mechanism where DPP-4 binds adenosine deaminase, which conveys intracellular signals via dimerization when activated. Saxagliptin forms a reversible, histidine-assisted covalent bond between its nitrile group and the S630 hydroxyl oxygen on DPP-4. The inhibition of DPP-4 increases levels active of glucagon like peptide 1 (GLP-1), which inhibits glucagon production from pancreatic alpha cells and increases production of insulin from pancreatic beta cells.

Dosage forms of Saxagliptin

Tablet, film coated, extended releaseoral
Film-coated tabletOral use2.5 mg

Prescription Generics


International Brands

Kombiglyze XR


(1S,3S,5S)-2-((2S)-Amino(3-hydroxytricyclo(,7)dec-1-yl)acetyl)-2-azabicyclo(3.1.0)hexane-3-carbonitrile BMS 477118


Astra Zeneca Pharmaceuticals Lp

CAS number






Affected organisms

Indication of Saxagliptin

Treatment of type 2 diabetes mellitus to improve glycemic control in combination with other agents or as monotherapy.

Toxicity of Saxagliptin

Adverse reactions reported in 5% of patients treated with saxagliptin and more commonly than in patients treated with placebo are: upper respiratory tract infection, urinary tract infection, and headache.

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What is Onglyza?

Onglyza is an oral diabetes medicine that helps control blood sugar levels. It works by regulating the levels of insulin that the body produces after eating.

Onglyza is for people with type 2 diabetes. It is sometimes used in combination with other drugs to treat diabetes, but not to treat type 1 diabetes.

You should not use Onglyza if you are in a state of diabetic ketoacidosis (consult your doctor for insulin treatment). It is not intended to treat type 1 diabetes. Before taking Onglyza, tell your doctor if you have kidney disease or if you are on dialysis.

Onglyza is only part of a complete treatment program, which also includes diet, exercise, weight control, and possibly other medications. It is important to use this medicine regularly to get the most benefit. Get a prescription filled before you run out of medicine.