Save up -80% on Secukinumab
Note: this is a drug discount program, not an insurance plan.
2018 Price of Cosentyx
* price without discount in nearest pharmacy. Price may vary.
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Secukinumab volume of distribution
Volume of distribution (Vd) in interstitial fluid of skin (+/- psoriasis) was 27-40% of that in serum after single subcutaneous dose of 300 mg. Vd increased at higher body weights.
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Secukinumab
Secukinumab (Cosentyx) is a human monoclonal antibody designed for the treatment of uveitis, rheumatoid arthritis, ankylosing spondylitis, and psoriasis. Secukinumab is an interleukin-17A (IL-17A) inhibitor marketed by Novartis. IL-17 is a group of proinflammatory cytokines released by cells of the immune system and and exist in higher levels in many immune conditions associated with chronic inflammation. By targeting IL-17A, secukinumab has shown excellent efficacy in psoriasis by normalizing skin histology and was approved by the United States Food and Drug Administration on January 21, 2015 to treat adults with moderate-to-severe plaque psoriasis.
Secukinumab mechanism of action
Secukinumab is a human monoclonal antibody that targets IL-17A cytokine to downregulate inflammation in psoriasis, an autoimmune dermatological disease. The pathophysiology of psoriasis has not been fully established, however it is known that dysregulation of innate and adaptive immune responses plays part in the chronic inflammation associated with the disease. IL-17 represents is a six-membered family (IL-17A to F) of pleiotropic pro-inflammatory cytokines, expression of which is found to be elevated in psoriatic skin. These cytokines act on many different cell types and provide defense against different extracellular pathogens causing fungal or bacterial infections. IL-17 cytokines are produced by many cells involved in immune system defense, such as Th17, mast cells, neutrophils, and dendritic cells – all implicated in promoting inflammation. There is evidence linking IL-17 to pathogenesis of multiple autoimmune diseases including rheumatoid arthritis, spondyloarthritis, psoriasis, Crohn’s disease, multiple sclerosis, and even atherosclerosis.
Dosage forms of Secukinumab
|Cosentyx||150mg/ml||1 sensoready pen||$4,687|
|Cosentyx||150mg/ml||2 sensoready pens||$4,813|
Novartis Pharmaceuticals Canada Inc
Humans and other mammals
Indication of Secukinumab
For the treatment of moderate to severe plaque psoriasis in patients that are candidates for systemic therapy or phototherapy.
Toxicity of Secukinumab
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