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RX BIN: 015558
RX PCN: HT
Group ID: DDN6600
Card Holder ID: DDN6600

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2018 Price of Selegiline

Apo-Selegiline 5 mg Tablet

$1.33

tablet

* price without discount in nearest pharmacy. Price may vary.

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Selegiline volume of distribution

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What is Selegiline

A selective, irreversible inhibitor of Type B monoamine oxidase. It is used in newly diagnosed patients with Parkinson‘s disease. It may slow progression of the clinical disease and delay the requirement for levodopa therapy. It also may be given with levodopa upon onset of disability. (From AMA Drug Evaluations Annual, 1994, p385) The compound without isomeric designation is Deprenyl.

Selegiline mechanism of action

Although the mechanisms for selegiline’s beneficial action in the treatment of Parkinson’s disease are not fully understood, the selective, irreversible inhibition of monoamine oxidase type B (MAO-B) is thought to be of primary importance. MAO-B is involved in the oxidative deamination of dopamine in the brain. Selegiline binds to MAO-B within the nigrostriatal pathways in the central nervous system, thus blocking microsomal metabolism of dopamine and enhancing the dopaminergic activity in the substantial nigra. Selegiline may also increase dopaminergic activity through mechanisms other than inhibition of MAO-B. At higher doses, selegiline can also inhibit monozmine oxidase type A (MAO-A), allowing it to be used for the treatment of depression.

Dosage forms of Selegiline

FormRouteStrength
Tabletoral5 mg
Patchtransdermal12 mg/24h
Patchtransdermal6 mg/24h
Prescription Generics

true

International Brands

Apo-selegiline

Synonyms

()-selegiline L-Deprenalin

Manufacturers

Apotex Inc

CAS number

14611-51-9

UNII

2K1V7GP655

State

solid

Affected organisms

Humans and other mammals

Indication of Selegiline

Monotherapy for initial treatment of Parkinson’s disease, as well as an adjunct therapy in patients with a decreased response to levodopa/carbadopa. Also used for the palliative treatment of mild to moderate Alzheimer’s disease and at higher doses, for the treatment of depression.

Toxicity of Selegiline

LD sub 50 /sub =63 mg/kg (rats, IV)

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