Save up -80% on Selegiline
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2018 Price of Selegiline
Apo-Selegiline 5 mg Tablet
* price without discount in nearest pharmacy. Price may vary.
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Selegiline volume of distribution
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Selegiline
A selective, irreversible inhibitor of Type B monoamine oxidase. It is used in newly diagnosed patients with Parkinson‘s disease. It may slow progression of the clinical disease and delay the requirement for levodopa therapy. It also may be given with levodopa upon onset of disability. (From AMA Drug Evaluations Annual, 1994, p385) The compound without isomeric designation is Deprenyl.
Selegiline mechanism of action
Although the mechanisms for selegiline’s beneficial action in the treatment of Parkinson’s disease are not fully understood, the selective, irreversible inhibition of monoamine oxidase type B (MAO-B) is thought to be of primary importance. MAO-B is involved in the oxidative deamination of dopamine in the brain. Selegiline binds to MAO-B within the nigrostriatal pathways in the central nervous system, thus blocking microsomal metabolism of dopamine and enhancing the dopaminergic activity in the substantial nigra. Selegiline may also increase dopaminergic activity through mechanisms other than inhibition of MAO-B. At higher doses, selegiline can also inhibit monozmine oxidase type A (MAO-A), allowing it to be used for the treatment of depression.
Dosage forms of Selegiline
Humans and other mammals
Indication of Selegiline
Monotherapy for initial treatment of Parkinson’s disease, as well as an adjunct therapy in patients with a decreased response to levodopa/carbadopa. Also used for the palliative treatment of mild to moderate Alzheimer’s disease and at higher doses, for the treatment of depression.
Toxicity of Selegiline
LD sub 50 /sub =63 mg/kg (rats, IV)
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