Save up -80% on Senna glycoside
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|RX BIN: 015558||RX PCN: HT||Group ID: DDN6600||Card Holder ID: DDN6600|
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Senna glycoside volume of distribution
Senna is administered orally and rectally. The pharmacokinetics of senna are not well characterized. There is insufficient evidence of distribution into breast milk, but amounts are unlikely to be a problem. Absorbed anthraquinones are believed to be metabolized by the liver and may be excreted via the bile in feces, and, possibly, in urine.
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Senna glycoside
Senna glycoside, also known as sennoside or senna, is a medication used to treat constipation and empty the large intestine before surgery. The medication is taken by mouth or via the rectum. It typically begins working in minutes when given by rectum and within twelve hours when given by mouth. It is a weaker laxative than bisacodyl or castor oil.
Senna glycoside mechanism of action
Senna derivatives are a type of stimulant laxative and are of the anthraquinone type. While its mechanism of action is not entirely clear, senna is thought to act by increasing fluid secretion within and contraction of the large intestine.
Dosage forms of Senna glycoside
Agarol Extra Strength Chewable Laxative Tablets
Numark Laboratories, Inc.
Indication of Senna glycoside
For the treatment of constipation.
Toxicity of Senna glycoside
Significant increases in the incidences of epithelial hyperplasia of the colon and cecum were observed at 10,000 ppm in p53+/− males and females, and the incidence of hyperplasia of the colon was significantly increased at 3,000 ppm in females. In conclusion, the large intestine was the major target of senna-induced toxicity in both wild-type and the p53+/− mouse model.
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