Save up -80% on Sevoflurane
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2018 Price of Sevoflurane
Ultane 250 ml pen bottle
* price without discount in nearest pharmacy. Price may vary.
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Sevoflurane volume of distribution
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Sevoflurane
Sevoflurane (2,2,2-trifluoro-1-(trifluoromethyl)ethyl fluoromethyl ether), also called fluoromethyl, is a sweet-smelling, non-flammable, highly fluorinated methyl isopropyl ether used for induction and maintenance of general anesthesia. Together with desflurane, it is replacing isoflurane and halothane in modern anesthesiology. (Wikipedia)
Sevoflurane mechanism of action
Sevoflurane induces a reduction in junctional conductance by decreasing gap junction channel opening times and increasing gap junction channel closing times. Sevoflurane also activates calcium dependent ATPase in the sarcoplasmic reticulum by increasing the fluidity of the lipid membrane. It also appears to bind the D subunit of ATP synthase and NADH dehydogenase and also binds to the GABA receptor, the large conductance Ca sup2+ /sup activated potassium channel, the glutamate receptor, and the glycine receptor.
Dosage forms of Sevoflurane
|Liquid||respiratory (inhalation)||1 mL/mL|
|Liquid||respiratory (inhalation)||250 mL/250mL|
Piramal Critical Care Inc
Humans and other mammals
Indication of Sevoflurane
Used for induction and maintenance of general anesthesia in adult and pediatric patients for inpatient and outpatient surgery.
Toxicity of Sevoflurane
LC sub50 /sub=49881 ppm/hr (rat), LD sub50 /sub=10.8 g/kg (rat)
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