Save up -80% on Sildenafil
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2019 Price of Viagra
|$15.33||10 tablets/100 mg|
|price without discount in nearest pharmacy. Price may vary.|
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Sildenafil volume of distribution
Absolute bioavailability of sildenafil is about 40%. Distribution: Widely distributed to body tissues with a mean steady state volume of distribution of 105 L. Both drug and its major active metabolite are 96% bound to plasma proteins. Protein-binding is independent of drug levels.
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What is Sildenafil
Sildenfail is a vasoactive agent used to treat erectile dysfunction and reduce symptoms in patients with pulmonary arterial hypertension (PAH). Sildenafil elevates levels of the second messenger, cGMP, by inhibiting its breakdown via phosphodiesterase type 5 (PDE5). PDE5 is found in particularly high concentrations in the corpus cavernosum, erectile tissue of the penis. It is also found in the retina and vascular endothelium. Increased cGMP results in vasodilation which facilitates generation and maintenance of an erection. The vasodilatory effects of sildenafil also help reduce symptoms of PAH.
Sildenafil mechanism of action
Sildenafil inhibits the cGMP-specific phosphodiesterase type 5 (PDE5) which is responsible for degradation of cGMP in the corpus cavernosum located around the penis. Penile erection during sexual stimulation is caused by increased penile blood flow resulting from the relaxation of penile arteries and corpus cavernosal smooth muscle. This response is mediated by the release of nitric oxide (NO) from nerve terminals and endothelial cells, which stimulates the synthesis of cGMP in smooth muscle cells. Cyclic GMP causes smooth muscle relaxation and increased blood flow into the corpus cavernosum. The inhibition of phosphodiesterase type 5 (PDE5) by sildenafil enhances erectile function by increasing the amount of cGMP.
Dosage forms of Sildenafil
Actavis Pharma Company
Humans and other mammals
Indication of Sildenafil
For the treatment of erectile dysfunction and to relieve symptoms of pulmonary arterial hypertension (PAH).
Toxicity of Sildenafil
In general, overdosage of sildenafil may be expected to produce effects that are extensions of common adverse reactions. In studies of healthy individuals receiving single sildenafil doses up to 800 mg, the types of adverse events (e.g., decreased blood pressure, syncope, and prolonged erection) observed were similar to those observed at lower doses, but the incidences were increased. Serious adverse effects have also been reported at therapeutic dose levels including sudden decrease or loss of hearing, sudden loss of vision in one or both eyes, and prolonged erection lasting greater than 4 hours or priapism (a painful erection lasting greater than 6 hours). Serious cardiovascular, cerebrovascular, and vascular events, including myocardial infarction, sudden cardiac death, ventricular arrhythmia, cerebrovascular hemorrhage, transient ischemic attack, hypertension, subarachnoid and intracerebral hemorrhages, and pulmonary hemorrhage have been reported post-marketing in temporal association with the use of sildenafil for erectile dysfunction. Most, but not all, of these patients had preexisting cardiovascular risk factors. Therefore it was not possible to determine whether these events were related directly to sildenafil, to sexual activity, to the patient’s underlying cardiovascular disease, to a combination of these factors, or to other factors. The use of sildenafil is not recommended in children. In a long-term trial in pediatric patients with PAH, an increase in mortality with increasing sildenafil dose was observed. Pulmonary vasodilators such as sildenafil may significantly worsen the cardiovascular status of patients with pulmonary veno-occlusive disease. Sildenafil profoundly potentiates the vasodilatory effects of organic nitrates and nitrites. The drug did not exhibit clastogenic potential in an in vitro human lymphocytes test system.
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What is a Viagra?
Viagra is a pill used to treat erectile dysfunction (impotence) in men. It helps most men with erectile dysfunction to achieve an erection and keep it from sexual arousal. You will not have an erection if you just take this drug. Viagra will help a man with erectile dysfunction to achieve an erection only if he is sexually excited.
Most patients are prescribed a dose of 50 mg. Take it should be an hour before the alleged sex. Not very convenient, but there is plenty of time for foreplay and erotic conversations.
But everyone reacts to the drug in its own way: 25 mg is enough for someone, and someone needs to increase the dose to 100 mg. Elderly patients and those who have diseases of the cardiovascular system, it is recommended to start all the same with a small dose of Viagra in 25 mg.
It is better not to take more than one pill per day, do not drink Sildenafil grapefruit juice (Viagra and Revatio). But you can take the drug for a long time, if not worried about side effects.