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Price of Sildenafil
Revatio 10 mg/12.5 ml vial
* price without discount in nearest pharmacy. Price may vary.
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Sildenafil volume of distribution
* 105 L
What is Sildenafil
Sildenfail is a vasoactive agent used to treat erectile dysfunction and reduce symptoms in patients with pulmonary arterial hypertension (PAH). Sildenafil elevates levels of the second messenger, cGMP, by inhibiting its breakdown via phosphodiesterase type 5 (PDE5). PDE5 is found in particularly high concentrations in the corpus cavernosum, erectile tissue of the penis. It is also found in the retina and vascular endothelium. Increased cGMP results in vasodilation which facilitates generation and maintenance of an erection. The vasodilatory effects of sildenafil also help reduce symptoms of PAH.
Sildenafil mechanism of action
Sildenafil inhibits the cGMP-specific phosphodiesterase type 5 (PDE5) which is responsible for degradation of cGMP in the corpus cavernosum located around the penis. Penile erection during sexual stimulation is caused by increased penile blood flow resulting from the relaxation of penile arteries and corpus cavernosal smooth muscle. This response is mediated by the release of nitric oxide (NO) from nerve terminals and endothelial cells, which stimulates the synthesis of cGMP in smooth muscle cells. Cyclic GMP causes smooth muscle relaxation and increased blood flow into the corpus cavernosum. The inhibition of phosphodiesterase type 5 (PDE5) by sildenafil enhances erectile function by increasing the amount of cGMP.
Dosage forms of Sildenafil
Actavis Pharma Company
Humans and other mammals
Indication of Sildenafil
For the treatment of erectile dysfunction and to relieve symptoms of pulmonary arterial hypertension (PAH).
Toxicity of Sildenafil
Disclaimer: before buying a Sildenafil on prescription, consult your health care provider. Content on this page is provided for informational purposes only. Any use of this information is at your own risk.