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RX BIN: 015558
RX PCN: HT
Group ID: DDN6600
Card Holder ID: DDN6600

Pharmacists and Patients support.

2018 Price of Sildenafil

Revatio 10 mg/12.5 ml vial

$9.33

ml

* price without discount in nearest pharmacy. Price may vary.

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Sildenafil volume of distribution

* 105 L

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What is Sildenafil

Sildenfail is a vasoactive agent used to treat erectile dysfunction and reduce symptoms in patients with pulmonary arterial hypertension (PAH). Sildenafil elevates levels of the second messenger, cGMP, by inhibiting its breakdown via phosphodiesterase type 5 (PDE5). PDE5 is found in particularly high concentrations in the corpus cavernosum, erectile tissue of the penis. It is also found in the retina and vascular endothelium. Increased cGMP results in vasodilation which facilitates generation and maintenance of an erection. The vasodilatory effects of sildenafil also help reduce symptoms of PAH.

Sildenafil mechanism of action

Sildenafil inhibits the cGMP-specific phosphodiesterase type 5 (PDE5) which is responsible for degradation of cGMP in the corpus cavernosum located around the penis. Penile erection during sexual stimulation is caused by increased penile blood flow resulting from the relaxation of penile arteries and corpus cavernosal smooth muscle. This response is mediated by the release of nitric oxide (NO) from nerve terminals and endothelial cells, which stimulates the synthesis of cGMP in smooth muscle cells. Cyclic GMP causes smooth muscle relaxation and increased blood flow into the corpus cavernosum. The inhibition of phosphodiesterase type 5 (PDE5) by sildenafil enhances erectile function by increasing the amount of cGMP.

Dosage forms of Sildenafil

DrugDosageQuantityPrice
Viagra25mg32 Tablet$248.00
Viagra50mg24 Tablet$158.95
Viagra100mg12 Tablet$89.30
Viagra100mg48 Tablet$333.25
Sildenafil25mg8 Tablet$19.40
Sildenafil50mg32 Tablet$30.85
Sildenafil100mg88 Tablet$72.00
Revatio20mg90 Tablet$900.00
Prescription Generics

false

International Brands

Act Sildenafil

Synonyms

1-((3-(4,7-Dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo(4,3-D)pyrimidin-5-yl)-4-ethoxyphenyl)sulfonyl)-4-methylpiperazine

Manufacturers

Actavis Pharma Company

CAS number

139755-83-2

UNII

3M7OB98Y7H

State

solid

Affected organisms

Humans and other mammals

Indication of Sildenafil

For the treatment of erectile dysfunction and to relieve symptoms of pulmonary arterial hypertension (PAH).

Toxicity of Sildenafil

RX24 Drugs Disclaimer: before buying a Sildenafil on prescription, consult your healthcare provider. Content on this page is provided for informational purposes only. Any use of this information is at your own risk.

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