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RX BIN: 015558
RX PCN: HT
Group ID: DDN6600
Card Holder ID: DDN6600

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2018 Price of Silodosin

$

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Silodosin volume of distribution

49.5 L

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What is Silodosin

Silodosin is an 1-adrenoceptor antagonist that is selective for the prostate. Silodosin is for symptomatic treatment of benign prostatic hyperplasia. FDA approved Oct 9, 2008.

Silodosin mechanism of action

Benign prostate hyperplasia (BPH), or an enlarged prostate, is a condition found only in men and is characterized by a non-cancerous enlargement of the prostate gland. Symptoms of BPH include urinary difficulty, urinary frequency and an inability to complete bladder emptying. Silodosin is highly uroselective for the alpha (1A) receptors located in the prostate,[urethrea and bladder trigone in the lower urinary tract]. Blocking these receptors relaxes the smooth muscles, resulting in an improvement in urine flow and a reduction in BPH symptoms. The selective binding of silodosin to the alpha (1A) receptors is substantially greater than the binding to the cardiovascular-associated alpha (1B) receptors and thereby maximizes target organ activity while minimizing the potential for blood pressure effects.[Watson Pharmaceutical Inc. Press release]Silodosin is alpha 1A-adrenoceptor selective antagonist which inhibits sympathetic nerve stimulation and relaxation of smooth muscle tone in the lower urinary tract which relieves the pressure from contraction of smooth muscle. The reduction of intraurethral pressure improves voiding and storage issues associated with BPH.

Dosage forms of Silodosin

FormRouteStrength
Capsuleoral4 mg/1
Capsuleoral4 mg
Capsuleoral8 mg
Prescription Generics

false

International Brands

Rapaflo

Synonyms

KAD 3213 KMD 3213

Manufacturers

Physicians Total Care, Inc.

CAS number

160970-54-7

UNII

CUZ39LUY82

State

solid

Affected organisms

Humans and other mammals

Indication of Silodosin

Treatment for symptomatic relief of benign prostatic hyperplasia

Toxicity of Silodosin

Most common adverse reactions (incidence 2%) are retrograde ejaculation, dizziness, diarrhea, orthostatic hypotension, headache, nasopharyngitis, and nasal congestion.

RX24 Drugs Disclaimer: before buying a Silodosin on prescription, consult your healthcare provider. Content on this page is provided for informational purposes only. Any use of this information is at your own risk.

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