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RX BIN: 015558
RX PCN: HT
Group ID: DDN6600
Card Holder ID: DDN6600

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2018 Price of Silver sulfadiazine

Silver Sulfadiazine 1% Cream 25 gm Jar

$13.99

jar

* price without discount in nearest pharmacy. Price may vary.

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Silver sulfadiazine volume of distribution

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What is Silver sulfadiazine

Silver sulfadiazine is a sulfa derivative topical antibacterial used primarily on second- and third-degree burns.[Wikipedia]

Silver sulfadiazine mechanism of action

Studies utilizing radioactive micronized silver sulfadiazine, electron microscopy, and biochemical techniques have revealed that the mechanism of action of silver sulfadiazine on bacteria differs from silver nitrate and sodium sulfadiazine. Silver sulfadiazine acts only on the cell membrane and cell wall to produce its bactericidal effect. A specific mechanism of action has not been determined, but silver sulfadiazine’s effectiveness may possibly be from a synergistic interaction, or the action of each component. Silver is a biocide, which binds to a broad range of targets. Silver ions bind to nucleophilic amino acids, as well as sulfhydryl, amino, imidazole, phosphate, and carboxyl groups in proteins, causing protein denaturation and enzyme inhibition. Silver binds to surface membranes and proteins, causing proton leaks in the membrane, leading to cell death. Sulfadiazine is a competitive inhibitor of bacterial para-aminobenzoic acid (PABA), a substrate of the enzyme dihydropteroate synthetase. The inhibited reaction is necessary in these organisms for the synthesis of folic acid.

Dosage forms of Silver sulfadiazine

FormRouteStrength
Creamtopical
Creamtopical1 %
Creamtopical10 g/1000g
Prescription Generics

false

International Brands

Dermazin Crm 1%

Synonyms

Flamazine Silvadene

Manufacturers

Pharmascience Inc

CAS number

22199-08-2

UNII

W46JY43EJR

State

solid

Affected organisms

Yeast and other fungi

Indication of Silver sulfadiazine

Indicated as an adjunct for the prevention and treatment of wound sepsis in patients with second- and third-degree burns.

Toxicity of Silver sulfadiazine

Acute oral toxicity (LD50) in rat is 10001 mg/kg.

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