Save up -80% on Silver sulfadiazine
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2018 Price of Silver sulfadiazine
Silver Sulfadiazine 1% Cream 25 gm Jar
* price without discount in nearest pharmacy. Price may vary.
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Silver sulfadiazine volume of distribution
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Silver sulfadiazine
Silver sulfadiazine is a sulfa derivative topical antibacterial used primarily on second- and third-degree burns.[Wikipedia]
Silver sulfadiazine mechanism of action
Studies utilizing radioactive micronized silver sulfadiazine, electron microscopy, and biochemical techniques have revealed that the mechanism of action of silver sulfadiazine on bacteria differs from silver nitrate and sodium sulfadiazine. Silver sulfadiazine acts only on the cell membrane and cell wall to produce its bactericidal effect. A specific mechanism of action has not been determined, but silver sulfadiazine’s effectiveness may possibly be from a synergistic interaction, or the action of each component. Silver is a biocide, which binds to a broad range of targets. Silver ions bind to nucleophilic amino acids, as well as sulfhydryl, amino, imidazole, phosphate, and carboxyl groups in proteins, causing protein denaturation and enzyme inhibition. Silver binds to surface membranes and proteins, causing proton leaks in the membrane, leading to cell death. Sulfadiazine is a competitive inhibitor of bacterial para-aminobenzoic acid (PABA), a substrate of the enzyme dihydropteroate synthetase. The inhibited reaction is necessary in these organisms for the synthesis of folic acid.
Dosage forms of Silver sulfadiazine
Dermazin Crm 1%
Yeast and other fungi
Indication of Silver sulfadiazine
Indicated as an adjunct for the prevention and treatment of wound sepsis in patients with second- and third-degree burns.
Toxicity of Silver sulfadiazine
Acute oral toxicity (LD50) in rat is 10001 mg/kg.
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