Save up -80% on Silver sulfadiazine
|Note: this is a drug discount program, not an insurance plan.|
|RX BIN: 015558||RX PCN: HT||Group ID: DDN6600||Card Holder ID: DDN6600|
|Pharmacists and Patients support.|
2019 Price of Silvadene
|$8.99||1 tube (50g) 1% cream|
|price without discount in nearest pharmacy. Price may vary.|
We offer free Silver sulfadiazine coupons and discounts that may help you save up to 80% off the retail price in your local pharmacy. Just print your coupon! It’s ready to use and never expire. Present your manufacturer copay card in most local pharmacies to get a discount on Silver sulfadiazine every time. What are you waiting for? Claim your prescription drug card now!
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Silver sulfadiazine volume of distribution
Very limited penetration through the skin. Only when applied to very large area burns is absorption into the body generally an issue.
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Silver sulfadiazine
Silver sulfadiazine is a sulfa derivative topical antibacterial used primarily on second- and third-degree burns.[Wikipedia]
Silver sulfadiazine mechanism of action
Studies utilizing radioactive micronized silver sulfadiazine, electron microscopy, and biochemical techniques have revealed that the mechanism of action of silver sulfadiazine on bacteria differs from silver nitrate and sodium sulfadiazine. Silver sulfadiazine acts only on the cell membrane and cell wall to produce its bactericidal effect. A specific mechanism of action has not been determined, but silver sulfadiazine’s effectiveness may possibly be from a synergistic interaction, or the action of each component. Silver is a biocide, which binds to a broad range of targets. Silver ions bind to nucleophilic amino acids, as well as sulfhydryl, amino, imidazole, phosphate, and carboxyl groups in proteins, causing protein denaturation and enzyme inhibition. Silver binds to surface membranes and proteins, causing proton leaks in the membrane, leading to cell death. Sulfadiazine is a competitive inhibitor of bacterial para-aminobenzoic acid (PABA), a substrate of the enzyme dihydropteroate synthetase. The inhibited reaction is necessary in these organisms for the synthesis of folic acid.
Dosage forms of Silver sulfadiazine
Dermazin Crm 1%
Yeast and other fungi
Indication of Silver sulfadiazine
Indicated as an adjunct for the prevention and treatment of wound sepsis in patients with second- and third-degree burns.
Toxicity of Silver sulfadiazine
Acute oral toxicity (LD50) in rat is 10001 mg/kg.
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