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RX BIN: 015558RX PCN: HTGroup ID: DDN6600Card Holder ID: DDN6600
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2019 Price of Vytorin

$72.1730 tablets/40 mg
price without discount in nearest pharmacy. Price may vary.

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We offer free Vytorin coupons and discounts that may help you save up to 80% off the retail price in your local pharmacy. Just print your coupon! It’s ready to use and never expire. Present your manufacturer copay card in most local pharmacies to get a discount on Simvastatin every time. What are you waiting for? Claim your prescription drug card now!

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Simvastatin volume of distribution

Following an oral dose of (14)C-labeled simvastatin in man, 13% of the dose was excreted in urine and 60% in feces. Plasma concentrations of total radioactivity (simvastatin plus (14)C-metabolites) peaked at 4 hours and declined rapidly to about 10% of peak by 12 hours postdose. Since simvastatin undergoes extensive first-pass extraction in the liver, the availability of the drug to the general circulation is low (<5%).

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2018 Statistics

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Discount Cards 16,000+

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Clients Benefit 29%

savings

Total savings $4,735,080

What is Simvastatin

Simvastatin is a lipid-lowering agent that is derived synthetically from the fermentation of Aspergillus terreus. It is a potent competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase (hydroxymethylglutaryl COA reductases), which is the rate-limiting enzyme in cholesterol biosynthesis. It may also interfere with steroid hormone production. Due to the induction of hepatic LDL receptors, it increases breakdown of LDL cholesterol.

Simvastatin mechanism of action

Simvastatin is a prodrug in which the 6-membered lactone ring of simvastatin is hydrolyzed iin vivo /i to generate the beta,delta-dihydroxy acid, an active metabolite structurally similar to HMG-CoA (hydroxymethylglutaryl CoA). Once hydrolyzed, simvastatin competes with HMG-CoA for HMG-CoA reductase, a hepatic microsomal enzyme. Interference with the activity of this enzyme reduces the quantity of mevalonic acid, a precursor of cholesterol.

Dosage forms of Simvastatin

DrugDosageQuantityPrice
Simvastatin10mg28 Tablet$24.00
Simvastatin20mg90 Tablet$54.00
Simvastatin20mg90 Tablet$54.00
Vytorin10/10mg90 Tablet$242.20
Vytorin10/20mg84 Tablet$184.70
Vytorin10/40mg28 Tablet$90.10
Vytorin10/80mg30 Tablet$145.00

Prescription Generics

false

International Brands

Act Simvastatin

Synonyms

2,2-Dimethylbutyric acid, 8-ester with (4R,6R)-6-(2-((1S,2S,6R,8S,8ar)-1,2,6,7,8,8a-hexahydro-8-hydroxy-2,6-dimethyl-1-naphthyl)ethyl)tetrahydro-4-hydroxy-2H-pyran-2-one MK-733

Manufacturers

Actavis Pharma Company

CAS number

79902-63-9

UNII

AGG2FN16EV

State

solid

Affected organisms

Humans and other mammals

Indication of Simvastatin

For the treatment of hypercholesterolemia and for the reduction in the risk of cardiac heart disease mortality and cardiovascular events. It can also be used in adolescent patients for the treatment of heterozygous familial hypercholesterolemia.

Toxicity of Simvastatin

The most common adverse reactions that lead to discontinuation of therapy include gastrointestinal disorders (0.5%), myalgia (0.1%), and arthralgia (0.1%).

RX24 Drugs Disclaimer: consult your healthcare provider before buying a Simvastatin on prescription or using an RX manufacturer savings coupon. Content on this page is provided for informational purposes only. Any use of this information is at your own risk.

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What is Vytorin?

Vytorin contains a combination of ezetimibe and simvastatin. Ezetimibe reduces the amount of cholesterol absorbed by the body. Simvastatin is in a group of drugs called HMG CoA reductase inhibitors, or “statins.”

Ezetimibe and simvastatin reduce the level of “bad” cholesterol in the blood (low density lipoprotein, or LDL) and triglycerides, while increasing the level of “good” cholesterol (high density lipoprotein or HDL).

Vytorin is used together with a low-fat diet and other treatments to lower total cholesterol in adults and children aged at least 10 years. It is not known whether your risk to reduce heart disease.

You should not use Vytorin if you have an active liver disease or abnormal liver function tests. The following medications should not be used while you are taking Vytorin: boceprevir, cyclosporine, danazol, gemfibrozil, nefazodone, telaprevir, some antibiotics (clarithromycin, erythromycin, telithromycin), antifungal drugs (itraconazole, ketoconazole, acyltrumcylcropyl). atazanavir, cobycystat (Stribild, Tybost), indinavir, nelfinavir, ritonavir, saquinavir, tipranavir).

Do not use Vytorin if you are pregnant or may become pregnant. Use effective birth control. Do not breast-feed while using Vytorin.