Save up -80% on Simvastatin

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RX BIN: 015558
Group ID: DDN6600
Card Holder ID: DDN6600

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2018 Price of Simvastatin

Apo-Simvastatin 10 mg Tablet



* price without discount in nearest pharmacy. Price may vary.

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Simvastatin volume of distribution

Simvastatin can cross the blood-brain-barrier.

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What is Simvastatin

Simvastatin is a lipid-lowering agent that is derived synthetically from the fermentation of Aspergillus terreus. It is a potent competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase (hydroxymethylglutaryl COA reductases), which is the rate-limiting enzyme in cholesterol biosynthesis. It may also interfere with steroid hormone production. Due to the induction of hepatic LDL receptors, it increases breakdown of LDL cholesterol.

Simvastatin mechanism of action

Simvastatin is a prodrug in which the 6-membered lactone ring of simvastatin is hydrolyzed iin vivo /i to generate the beta,delta-dihydroxy acid, an active metabolite structurally similar to HMG-CoA (hydroxymethylglutaryl CoA). Once hydrolyzed, simvastatin competes with HMG-CoA for HMG-CoA reductase, a hepatic microsomal enzyme. Interference with the activity of this enzyme reduces the quantity of mevalonic acid, a precursor of cholesterol.

Dosage forms of Simvastatin

Simvastatin10mg28 Tablet$24.00
Simvastatin20mg90 Tablet$54.00
Simvastatin20mg90 Tablet$54.00
Vytorin10/10mg90 Tablet$242.20
Vytorin10/20mg84 Tablet$184.70
Vytorin10/40mg28 Tablet$90.10
Vytorin10/80mg30 Tablet$145.00
Prescription Generics


International Brands

Act Simvastatin


2,2-Dimethylbutyric acid, 8-ester with (4R,6R)-6-(2-((1S,2S,6R,8S,8ar)-1,2,6,7,8,8a-hexahydro-8-hydroxy-2,6-dimethyl-1-naphthyl)ethyl)tetrahydro-4-hydroxy-2H-pyran-2-one MK-733


Actavis Pharma Company

CAS number






Affected organisms

Humans and other mammals

Indication of Simvastatin

For the treatment of hypercholesterolemia and for the reduction in the risk of cardiac heart disease mortality and cardiovascular events. It can also be used in adolescent patients for the treatment of heterozygous familial hypercholesterolemia.

Toxicity of Simvastatin

The most common adverse reactions that lead to discontinuation of therapy include gastrointestinal disorders (0.5%), myalgia (0.1%), and arthralgia (0.1%).

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