Save up -80% on Simvastatin
|Note: this is a drug discount program, not an insurance plan.|
|RX BIN: 015558||RX PCN: HT||Group ID: DDN6600||Card Holder ID: DDN6600|
|Pharmacists and Patients support.|
2019 Price of Vytorin
|$72.17||30 tablets/40 mg|
|price without discount in nearest pharmacy. Price may vary.|
We offer free Vytorin coupons and discounts that may help you save up to 80% off the retail price in your local pharmacy. Just print your coupon! It’s ready to use and never expire. Present your manufacturer copay card in most local pharmacies to get a discount on Simvastatin every time. What are you waiting for? Claim your prescription drug card now!
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Simvastatin volume of distribution
Following an oral dose of (14)C-labeled simvastatin in man, 13% of the dose was excreted in urine and 60% in feces. Plasma concentrations of total radioactivity (simvastatin plus (14)C-metabolites) peaked at 4 hours and declined rapidly to about 10% of peak by 12 hours postdose. Since simvastatin undergoes extensive first-pass extraction in the liver, the availability of the drug to the general circulation is low (<5%).
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Simvastatin
Simvastatin is a lipid-lowering agent that is derived synthetically from the fermentation of Aspergillus terreus. It is a potent competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase (hydroxymethylglutaryl COA reductases), which is the rate-limiting enzyme in cholesterol biosynthesis. It may also interfere with steroid hormone production. Due to the induction of hepatic LDL receptors, it increases breakdown of LDL cholesterol.
Simvastatin mechanism of action
Simvastatin is a prodrug in which the 6-membered lactone ring of simvastatin is hydrolyzed iin vivo /i to generate the beta,delta-dihydroxy acid, an active metabolite structurally similar to HMG-CoA (hydroxymethylglutaryl CoA). Once hydrolyzed, simvastatin competes with HMG-CoA for HMG-CoA reductase, a hepatic microsomal enzyme. Interference with the activity of this enzyme reduces the quantity of mevalonic acid, a precursor of cholesterol.
Dosage forms of Simvastatin
2,2-Dimethylbutyric acid, 8-ester with (4R,6R)-6-(2-((1S,2S,6R,8S,8ar)-1,2,6,7,8,8a-hexahydro-8-hydroxy-2,6-dimethyl-1-naphthyl)ethyl)tetrahydro-4-hydroxy-2H-pyran-2-one MK-733
Actavis Pharma Company
Humans and other mammals
Indication of Simvastatin
For the treatment of hypercholesterolemia and for the reduction in the risk of cardiac heart disease mortality and cardiovascular events. It can also be used in adolescent patients for the treatment of heterozygous familial hypercholesterolemia.
Toxicity of Simvastatin
The most common adverse reactions that lead to discontinuation of therapy include gastrointestinal disorders (0.5%), myalgia (0.1%), and arthralgia (0.1%).
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What is Vytorin?
Vytorin contains a combination of ezetimibe and simvastatin. Ezetimibe reduces the amount of cholesterol absorbed by the body. Simvastatin is in a group of drugs called HMG CoA reductase inhibitors, or “statins.”
Ezetimibe and simvastatin reduce the level of “bad” cholesterol in the blood (low density lipoprotein, or LDL) and triglycerides, while increasing the level of “good” cholesterol (high density lipoprotein or HDL).
Vytorin is used together with a low-fat diet and other treatments to lower total cholesterol in adults and children aged at least 10 years. It is not known whether your risk to reduce heart disease.
You should not use Vytorin if you have an active liver disease or abnormal liver function tests. The following medications should not be used while you are taking Vytorin: boceprevir, cyclosporine, danazol, gemfibrozil, nefazodone, telaprevir, some antibiotics (clarithromycin, erythromycin, telithromycin), antifungal drugs (itraconazole, ketoconazole, acyltrumcylcropyl). atazanavir, cobycystat (Stribild, Tybost), indinavir, nelfinavir, ritonavir, saquinavir, tipranavir).
Do not use Vytorin if you are pregnant or may become pregnant. Use effective birth control. Do not breast-feed while using Vytorin.