Save up -80% on Sirolimus
Note: this is a drug discount program, not an insurance plan.
2018 Price of Sirolimus
Rapamune 0.5 mg tablet
* price without discount in nearest pharmacy. Price may vary.
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Sirolimus volume of distribution
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Sirolimus
A macrolide compound obtained from Streptomyces hygroscopicus that acts by selectively blocking the transcriptional activation of cytokines thereby inhibiting cytokine production. It is bioactive only when bound to immunophilins. Sirolimus is a potent immunosuppressant and possesses both antifungal and antineoplastic properties.
Sirolimus mechanism of action
Sirolimus inhibits T lymphocyte activation and proliferation that occurs in response to antigenic and cytokine (Interleukin IL-2, IL-4, and IL-15) stimulation by a mechanism that is distinct from that of other immunosuppressants. Sirolimus also inhibits antibody production. In cells, sirolimus binds to the immunophilin, FK Binding Protein-12 (FKBP-12), to generate an immunosuppressive complex. The sirolimus:FKBP-12 complex has no effect on calcineurin activity. This complex binds to and inhibits the activation of the mammalian Target Of Rapamycin (mTOR), a key regulatory kinase. This inhibition suppresses cytokine-driven T-cell proliferation, inhibiting the progression from the G1 to the S phase of the cell cycle.
Dosage forms of Sirolimus
Genmed A Division Of Pfizer Canada Inc
Humans and other mammals
Indication of Sirolimus
For the prophylaxis of organ rejection in patients receiving renal transplants.
Toxicity of Sirolimus
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