Save up -80% on Sirolimus

Note: this is a drug discount program, not an insurance plan.
RX BIN: 015558RX PCN: HTGroup ID: DDN6600Card Holder ID: DDN6600
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2019 Price of Rapamune

$160.375 tablets/1mg
Price with discount in nearest pharmacy. Price may vary.

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We offer free Rapamune coupons and discounts that may help you save up to 80% off the retail price in your local pharmacy. Just print your coupon! It’s ready to use and never expire. Present your manufacturer copay card in most local pharmacies to get a discount on Sirolimus every time. What are you waiting for? Claim your prescription drug card now!

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Sirolimus volume of distribution

Sirolimus total body clearance is 278 ml/h/kg with an apparent volume of distribution of 22.8 l/kg. This large distribution volume implies extensive distribution to organs and tissues, and contributes to the long half-life. Sirolimus is partitioned extensively into blood cells with a blood to plasma ratio of 35.6.

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About RX24Drugs

2018 Statistics

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Discount Cards 16,000+


Clients Benefit 29%


Total savings $4,735,080

What is Sirolimus

A macrolide compound obtained from Streptomyces hygroscopicus that acts by selectively blocking the transcriptional activation of cytokines thereby inhibiting cytokine production. It is bioactive only when bound to immunophilins. Sirolimus is a potent immunosuppressant and possesses both antifungal and antineoplastic properties.

Sirolimus mechanism of action

Sirolimus inhibits T lymphocyte activation and proliferation that occurs in response to antigenic and cytokine (Interleukin IL-2, IL-4, and IL-15) stimulation by a mechanism that is distinct from that of other immunosuppressants. Sirolimus also inhibits antibody production. In cells, sirolimus binds to the immunophilin, FK Binding Protein-12 (FKBP-12), to generate an immunosuppressive complex. The sirolimus:FKBP-12 complex has no effect on calcineurin activity. This complex binds to and inhibits the activation of the mammalian Target Of Rapamycin (mTOR), a key regulatory kinase. This inhibition suppresses cytokine-driven T-cell proliferation, inhibiting the progression from the G1 to the S phase of the cell cycle.

Dosage forms of Sirolimus

Sirolimus1mg90 Tablet$450.00
Rapamune1mg90 Tablet$806.00

Prescription Generics


International Brands



(-)-Rapamycin Rapamycin


Genmed A Division Of Pfizer Canada Inc

CAS number






Affected organisms

Humans and other mammals

Indication of Sirolimus

For the prophylaxis of organ rejection in patients receiving renal transplants.

Toxicity of Sirolimus

The major toxicities associated with sirolimus treatment are thrombocytopenia and hyperlipidemia. In addition, concern has been raised by the higher serum creatinine levels noted in patients receiving sirolimus and cyclosporine compared with controls receiving cyclosporine and azathioprine.

RX24 Drugs Disclaimer: consult your healthcare provider before buying a Sirolimus on prescription or using an RX manufacturer savings coupon. Content on this page is provided for informational purposes only. Any use of this information is at your own risk.

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