Save up -80% on Sirolimus

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RX BIN: 015558
RX PCN: HT
Group ID: DDN6600
Card Holder ID: DDN6600

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2018 Price of Sirolimus

Rapamune 0.5 mg tablet

$5.86

tablet

* price without discount in nearest pharmacy. Price may vary.

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Sirolimus volume of distribution

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What is Sirolimus

A macrolide compound obtained from Streptomyces hygroscopicus that acts by selectively blocking the transcriptional activation of cytokines thereby inhibiting cytokine production. It is bioactive only when bound to immunophilins. Sirolimus is a potent immunosuppressant and possesses both antifungal and antineoplastic properties.

Sirolimus mechanism of action

Sirolimus inhibits T lymphocyte activation and proliferation that occurs in response to antigenic and cytokine (Interleukin IL-2, IL-4, and IL-15) stimulation by a mechanism that is distinct from that of other immunosuppressants. Sirolimus also inhibits antibody production. In cells, sirolimus binds to the immunophilin, FK Binding Protein-12 (FKBP-12), to generate an immunosuppressive complex. The sirolimus:FKBP-12 complex has no effect on calcineurin activity. This complex binds to and inhibits the activation of the mammalian Target Of Rapamycin (mTOR), a key regulatory kinase. This inhibition suppresses cytokine-driven T-cell proliferation, inhibiting the progression from the G1 to the S phase of the cell cycle.

Dosage forms of Sirolimus

DrugDosageQuantityPrice
Sirolimus1mg90 Tablet$450.00
Rapamune1mg90 Tablet$806.00
Prescription Generics

false

International Brands

Gd-sirolimus

Synonyms

(-)-Rapamycin Rapamycin

Manufacturers

Genmed A Division Of Pfizer Canada Inc

CAS number

53123-88-9

UNII

W36ZG6FT64

State

solid

Affected organisms

Humans and other mammals

Indication of Sirolimus

For the prophylaxis of organ rejection in patients receiving renal transplants.

Toxicity of Sirolimus

RX24 Drugs Disclaimer: before buying a Sirolimus on prescription, consult your healthcare provider. Content on this page is provided for informational purposes only. Any use of this information is at your own risk.

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