Save up -80% on Sirolimus
|Note: this is a drug discount program, not an insurance plan.|
|RX BIN: 015558||RX PCN: HT||Group ID: DDN6600||Card Holder ID: DDN6600|
|Pharmacists and Patients support.|
2019 Price of Rapamune
|Price with discount in nearest pharmacy. Price may vary.|
We offer free Rapamune coupons and discounts that may help you save up to 80% off the retail price in your local pharmacy. Just print your coupon! It’s ready to use and never expire. Present your manufacturer copay card in most local pharmacies to get a discount on Sirolimus every time. What are you waiting for? Claim your prescription drug card now!
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Sirolimus volume of distribution
Sirolimus total body clearance is 278 ml/h/kg with an apparent volume of distribution of 22.8 l/kg. This large distribution volume implies extensive distribution to organs and tissues, and contributes to the long half-life. Sirolimus is partitioned extensively into blood cells with a blood to plasma ratio of 35.6.
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Sirolimus
A macrolide compound obtained from Streptomyces hygroscopicus that acts by selectively blocking the transcriptional activation of cytokines thereby inhibiting cytokine production. It is bioactive only when bound to immunophilins. Sirolimus is a potent immunosuppressant and possesses both antifungal and antineoplastic properties.
Sirolimus mechanism of action
Sirolimus inhibits T lymphocyte activation and proliferation that occurs in response to antigenic and cytokine (Interleukin IL-2, IL-4, and IL-15) stimulation by a mechanism that is distinct from that of other immunosuppressants. Sirolimus also inhibits antibody production. In cells, sirolimus binds to the immunophilin, FK Binding Protein-12 (FKBP-12), to generate an immunosuppressive complex. The sirolimus:FKBP-12 complex has no effect on calcineurin activity. This complex binds to and inhibits the activation of the mammalian Target Of Rapamycin (mTOR), a key regulatory kinase. This inhibition suppresses cytokine-driven T-cell proliferation, inhibiting the progression from the G1 to the S phase of the cell cycle.
Dosage forms of Sirolimus
Genmed A Division Of Pfizer Canada Inc
Humans and other mammals
Indication of Sirolimus
For the prophylaxis of organ rejection in patients receiving renal transplants.
Toxicity of Sirolimus
The major toxicities associated with sirolimus treatment are thrombocytopenia and hyperlipidemia. In addition, concern has been raised by the higher serum creatinine levels noted in patients receiving sirolimus and cyclosporine compared with controls receiving cyclosporine and azathioprine.
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