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RX BIN: 015558
Group ID: DDN6600
Card Holder ID: DDN6600

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2018 Price of Sitagliptin

Januvia 100 mg tablet



* price without discount in nearest pharmacy. Price may vary.

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Sitagliptin volume of distribution

JanuviaTablet, film coated50 mg/1OralCardinal Health
RistabenTablet, film coated50 mgOralMerck Sharp & Dohme Limited
TesavelTablet, film coated100 mgOralMerck Sharp & Dohme Limited
XeleviaTablet, film coated25 mgOralMerck Sharp & Dohme Limited

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What is Sitagliptin

Sitagliptin is a new oral hypoglycemic (anti-diabetic drug) of the new dipeptidyl peptidase-4 (DPP-4) inhibitor class of drugs. This enzyme-inhibiting drug is to be used either alone or in combination with metformin or a thiazolidinedione for control of type 2 diabetes mellitus. The drug works to competitively inhibit a protein/enzyme, dipeptidyl peptidase 4 (DPP-4), that results in an increased amount of active incretins (GLP-1 and GIP), reduced amount of release of glucagon (diminishes its release) and increased release of insulin.

Sitagliptin mechanism of action

Sitagliptin is a highly selective DPP-4 inhibitor, which is believed to exert its actions in patients with type 2 diabetes by slowing the inactivation of incretin hormones, thereby increasing the concentration and prolonging the action of these hormones. Incretin hormones, including glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), are released by the intestine throughout the day, and levels are increased in response to a meal. These hormones are rapidly inactivated by the enzyme, DPP-4. The incretins are part of an endogenous system involved in the physiologic regulation of glucose homeostasis. When blood glucose concentrations are normal or elevated, GLP-1 and GIP increase insulin synthesis and release from pancreatic beta cells by intracellular signaling pathways involving cyclic AMP. GLP-1 also lowers glucagon secretion from pancreatic alpha cells, leading to reduced hepatic glucose production. By increasing and prolonging active incretin levels, sitagliptin increases insulin release and decreases glucagon levels in the circulation in a glucose-dependent manner. These changes lead to a decrease in hemoglobin A1c (HbA1c)levels, as well as a lower fasting and postprandial glucose concentration. Sitagliptin demonstrates selectivity for DPP-4 and does not inhibit DPP-8 or DPP-9 activity in vitro at concentrations approximating those from therapeutic doses.

Dosage forms of Sitagliptin

Januvia25mg84 Tablet$114.75
Januvia50mg84 Tablet$75.10
Januvia100mg84 Tablet$234.00
Janumet50/500mg90 Tablet$126.00
Janumet50/850mg56 Tablet$133.00
Janumet50/1000mg90 Tablet$130.00
Janumet XR50/1000mg56 Extended Release Tablet$180.00
Janumet XR100/1000mg28 Extended Release Tablet$239.00
Prescription Generics


International Brands



Januvia, Ristaben, Tesavel, Xelevia


AS Medication Solutions, Cardinal Health, Lake Erie Medical&Surgical Supply, Merck Ltd, Merck Sharp & Dohme Limited, Physicians Total Care, Remedy Repack

CAS number






Affected organisms

Humans and other mammals

Indication of Sitagliptin

For use as an adjunct to diet and exercise to improve glycemic control in patients with type 2 diabetes mellitus. Also for use in patients with type 2 diabetes mellitus to improve glycemic control in combination with metformin or a PPAR. agonist (e.g., thiazolidinediones) when the single agent alone, with diet and exercise, does not provide adequate glycemic control.

Toxicity of Sitagliptin

RX24 Drugs Disclaimer: before buying a Sitagliptin on prescription, consult your healthcare provider. Content on this page is provided for informational purposes only. Any use of this information is at your own risk.

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