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RX BIN: 015558RX PCN: HTGroup ID: DDN6600Card Holder ID: DDN6600
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2019 Price of Vesicare

$368.9830 tablets/10 mg
price without discount in nearest pharmacy. Price may vary.

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Solifenacin volume of distribution

Solifenacin has an apparent volume of distribution of 600 L, is 93-96% plasma protein bound, and probably crosses the blood-brain barrier. Solifenacin is eliminated mainly through hepatic metabolism via cytochrome P450 (CYP) 3A4, with about only 7% (3-13%) of the dose being excreted unchanged in the urine.

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What is Solifenacin

Solifenacin (rINN), marketed as solifenacin succinate under the trade name Vesicare, is a urinary antispasmodic of the anticholinergic class. It is used in the treatment of overactive bladder with urge incontinence.[Wikipedia]

Solifenacin mechanism of action

Solifenacin is a competitive muscarinic acetylcholine receptor antagonist. The binding of acetylcholine to these receptors, particularly the M3 receptor subtype, plays a critical role in the contraction of smooth muscle. By preventing the binding of acetylcholine to these receptors, solifenacin reduces smooth muscle tone in the bladder, allowing the bladder to retain larger volumes of urine and reducing the number of incontinence episodes.

Dosage forms of Solifenacin

Solifenacin5mg100 Tablet$28.95
Solifenacin10mg100 Tablet$43.90
Vesicare5mg30 Tablet$59.90
Vesicare5mg90 Tablet$96.70
Vesicare10mg30 Tablet$40.45
Vesicare10mg90 Tablet$101.25

Prescription Generics


International Brands

Act Solifenacin



Actavis Pharma Company

CAS number






Affected organisms

Humans and other mammals

Indication of Solifenacin

For the treatment of overactive bladder with symptoms of urge urinary incontinence, urgency, and urinary frequency.

Toxicity of Solifenacin

Overdosage with solifenacin can potentially result in severe anticholinergic effects and should be treated accordingly. The highest solifenacin dose given to human volunteers was a single 100 mg dose. Intolerable anticholinergic side effects (fixed and dilated pupils, blurred vision, failure of heel-to-toe exam, tremors and dry skin) occurred on day 3 in normal volunteers taking 50 mg daily (5 times the maximum recommended therapeutic dose).

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What is a Vesicare?

Vesicare – antispasmodic, it is a specific competitive inhibitor of muscarinic cholinergic receptors, mainly M3-subtype. It has also been found that solifenacin has a low affinity or lack of affinity for various other receptors and ion channels.

The efficacy of Vesicare when used in doses of 5 mg and 10 mg in overactive bladder syndrome is observed during the first week of treatment and stabilizes over the next 12 weeks of treatment. The maximum Vesicare effect can be detected after 4 weeks. Efficiency persists for prolonged use (at least 12 months).

After ingestion of Cmax in blood plasma is reached after 3-8 hours. Absolute bioavailability is 90%. Eating does not affect the Cmax and AUC of solifenacin. The pharmacokinetics of drug are linear in the therapeutic dose range. Vesicare is extensively metabolized in the liver, predominantly by the CYP3A4 isoenzyme. However, there are alternative metabolic pathways for solifenacin. The systemic clearance of Vesicare is about 9.5 l/h, and the final T1/2 is 45-68 h. After taking the drug inside the plasma, in addition to solifenacin, the following metabolites were identified: one pharmacologically active and three inactive. After a single injection, about 70% of the radioactivity was detected in the urine and 23% in the feces. In the urine, about 11% of the radioactivity was detected as unchanged active substance, about 18% as N-oxide metabolite, 9% as 4R-hydroxy-N-solifenacin oxide and 8% as 4R-hydroxy metabolite.