Save up -80% on Sorafenib

Note: this is a drug discount program, not an insurance plan.
RX BIN: 015558RX PCN: HTGroup ID: DDN6600Card Holder ID: DDN6600
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2019 Price of Nexavar

$9,196.6160 tablets/200 mg
price without discount in nearest pharmacy. Price may vary.

Claim your free Sorafenib discount card

We offer free Sorafenib coupons and discounts that may help you save up to 80% off the retail price in your local pharmacy. Just print your coupon! It’s ready to use and never expire. Present your manufacturer copay card in most local pharmacies to get a discount on Sorafenib every time. What are you waiting for? Claim your prescription drug card now!

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Sorafenib volume of distribution

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About RX24Drugs

2018 Statistics

discount card

Discount Cards 16,000+

benefit

Clients Benefit 29%

savings

Total savings $4,735,080

What is Sorafenib

Sorafenib (rINN), marketed as Nexavar by Bayer, is a drug approved for the treatment of advanced renal cell carcinoma (primary kidney cancer). It has also received “Fast Track” designation by the FDA for the treatment of advanced hepatocellular carcinoma (primary liver cancer), and has since performed well in Phase III trials. Sorafenib is a small molecular inhibitor of Raf kinase, PDGF (platelet-derived growth factor), VEGF receptor 2 3 kinases and c Kit the receptor for Stem cell factor. A growing number of drugs target most of these pathways. The originality of Sorafenib lays in its simultaneous targeting of the Raf/Mek/Erk pathway.

Sorafenib mechanism of action

Sorafenib interacts with multiple intracellular (CRAF, BRAF and mutant BRAF) and cell surface kinases (KIT, FLT-3, VEGFR-2, VEGFR-3, and PDGFR- szlig;). Several of these kinases are thought to be involved in angiogenesis, thus sorafenib reduces blood flow to the tumor. Sorafenib is unique in targeting the Raf/Mek/Erk pathway. By inhibiting these kinases, genetic transcription involving cell proliferation and angiogenesis is inhibited.

Dosage forms of Sorafenib

FormRouteStrength
Film-coated tabletOral use200 mg
Tabletoral200 mg
Tablet, film coatedoral200 mg/1

Prescription Generics

false

International Brands

Nexavar

Synonyms

4-(4-((((4-Chloro-3-(trifluoromethyl)phenyl)amino)carbonyl)amino)phenoxy)-N-methyl-2-pyridinecarboxamide N-(4-Chloro-3-(trifluoromethyl)phenyl)-n’-(4-(2-(N-methylcarbamoyl)-4-pyridyloxy)phenyl)urea

Manufacturers

Bayer Health Care Pharmaceuticals Inc.

CAS number

284461-73-0

UNII

9ZOQ3TZI87

State

solid

Affected organisms

Humans and other mammals

Indication of Sorafenib

Sorafenib is indicated for the treatment of unresectable hepatocellular carcinoma and advanced renal cell carcinoma.

Toxicity of Sorafenib

The highest dose of sorafenib studied clinically is 800 mg twice daily. The adverse reactions observed at this dose were primarily diarrhea and dermatologic events. No information is available on symptoms of acute overdose in animals because of the saturation of absorption in oral acute toxicity studies conducted in animals.

RX24 Drugs Disclaimer: consult your healthcare provider before buying a Sorafenib on prescription or using an RX manufacturer savings coupon. Content on this page is provided for informational purposes only. Any use of this information is at your own risk.

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