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RX BIN: 015558
RX PCN: HT
Group ID: DDN6600
Card Holder ID: DDN6600

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2018 Price of Sotalol

Sotalol 80 mg tablet

$2.35

tablet

* price without discount in nearest pharmacy. Price may vary.

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Sotalol volume of distribution

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What is Sotalol

An adrenergic beta-antagonist that is used in the treatment of life-threatening arrhythmias.

Sotalol mechanism of action

Sotalol has both beta-adrenoreceptor blocking (Vaughan Williams Class I) and cardiac action potential duration prolongation (Vaughan Williams Class I) antiarrhythmic properties. Sotalol is a racemic mixture of d- and l-sotalol. Both isomers have similar Class I antiarrhythmic effects, while the l-isomer is responsible for virtually all of the beta-blocking activity. Sotalol inhibits response to adrenergic stimuli by competitively blocking . sub1 /sub-adrenergic receptors within the myocardium and . sub2 /sub-adrenergic receptors within bronchial and vascular smooth muscle. The electrophysiologic effects of sotalol may be due to its selective inhibition of the rapidly activating component of the potassium channel involved in the repolarization of cardiac cells. The class II electrophysiologic effects are caused by an increase in sinus cycle length (slowed heart rate), decreased AV nodal conduction, and increased AV nodal refractoriness, while the class III electrophysiological effects include prolongation of the atrial and ventricular monophasic action potentials, and effective refractory period prolongation of atrial muscle, ventricular muscle, and atrio-ventricular accessory pathways (where present) in both the anterograde and retrograde directions.

Dosage forms of Sotalol

FormRouteStrength
Tabletoral160 mg
Tabletoral80 mg
Tabletoral240 mg
Prescription Generics

true

International Brands

Apo-sotalol – Tab 160mg

Synonyms

4′-(1-Hydroxy-2-(isopropylamino)ethyl)methane sulfonanilide beta-Cardone

Manufacturers

Apotex Inc

CAS number

3930-20-9

UNII

A6D97U294I

State

solid

Affected organisms

Humans and other mammals

Indication of Sotalol

For the maintenance of normal sinus rhythm (delay in time to recurrence of atrial fibrillation/atrial flutter (AFIB/AFL)) in patients with symptomatic AFIB/AFL who are currently in sinus rhythm. Also for the treatment of documented life-threatening ventricular arrhythmias.

Toxicity of Sotalol

The most common signs to be expected are bradycardia, congestive heart failure, hypotension, bronchospasm and hypoglycemia. In cases of massive intentional overdosage (2-16 grams) of sotalol the following clinical findings were seen: hypotension, bradycardia, cardiac asystole, prolongation of QT interval, Torsade de Pointes, ventricular tachy-cardia, and premature ventricular complexes.

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