Save up -80% on Sotalol
|Note: this is a drug discount program, not an insurance plan.|
|RX BIN: 015558||RX PCN: HT||Group ID: DDN6600||Card Holder ID: DDN6600|
|Pharmacists and Patients support.|
2019 Price of Betapace
|$13.35||60 tablets/80 mg|
|Price with discount in nearest pharmacy. Price may vary.|
We offer free Sotalol coupons and discounts that may help you save up to 80% off the retail price in your local pharmacy. Just print your coupon! It’s ready to use and never expire. Present your manufacturer copay card in most local pharmacies to get a discount on Sotalol every time. What are you waiting for? Claim your prescription drug card now!
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Sotalol volume of distribution
The drug has an apparent volume of distribution of 1.2–2.4 liters/kg.
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Sotalol
An adrenergic beta-antagonist that is used in the treatment of life-threatening arrhythmias.
Sotalol mechanism of action
Sotalol has both beta-adrenoreceptor blocking (Vaughan Williams Class I) and cardiac action potential duration prolongation (Vaughan Williams Class I) antiarrhythmic properties. Sotalol is a racemic mixture of d- and l-sotalol. Both isomers have similar Class I antiarrhythmic effects, while the l-isomer is responsible for virtually all of the beta-blocking activity. Sotalol inhibits response to adrenergic stimuli by competitively blocking . sub1 /sub-adrenergic receptors within the myocardium and . sub2 /sub-adrenergic receptors within bronchial and vascular smooth muscle. The electrophysiologic effects of sotalol may be due to its selective inhibition of the rapidly activating component of the potassium channel involved in the repolarization of cardiac cells. The class II electrophysiologic effects are caused by an increase in sinus cycle length (slowed heart rate), decreased AV nodal conduction, and increased AV nodal refractoriness, while the class III electrophysiological effects include prolongation of the atrial and ventricular monophasic action potentials, and effective refractory period prolongation of atrial muscle, ventricular muscle, and atrio-ventricular accessory pathways (where present) in both the anterograde and retrograde directions.
Dosage forms of Sotalol
Apo-sotalol – Tab 160mg
4′-(1-Hydroxy-2-(isopropylamino)ethyl)methane sulfonanilide beta-Cardone
Humans and other mammals
Indication of Sotalol
For the maintenance of normal sinus rhythm (delay in time to recurrence of atrial fibrillation/atrial flutter (AFIB/AFL)) in patients with symptomatic AFIB/AFL who are currently in sinus rhythm. Also for the treatment of documented life-threatening ventricular arrhythmias.
Toxicity of Sotalol
The most common signs to be expected are bradycardia, congestive heart failure, hypotension, bronchospasm and hypoglycemia. In cases of massive intentional overdosage (2-16 grams) of sotalol the following clinical findings were seen: hypotension, bradycardia, cardiac asystole, prolongation of QT interval, Torsade de Pointes, ventricular tachy-cardia, and premature ventricular complexes.
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