Save up -80% on Spironolactone
Note: this is a drug discount program, not an insurance plan.
Price of Spironolactone
Aldactazide 25-25 tablet
* price without discount in nearest pharmacy. Price may vary.
We offer free Spironolactone coupons and discounts that may help you save up to 80% off the retail price in your local pharmacy. Just print your coupon! It’s ready to use and never expire. Present your coupon in most local pharmacies to get a discount on Spironolactone. Claim your prescription drug card now!
Spironolactone volume of distribution
What is Spironolactone
A potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatment of refractory edema in patients with congestive heart failure, nephrotic syndrome, or hepatic cirrhosis. Its effects on the endocrine system are utilized in the treatments of hirsutism and acne but they can lead to adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p827)
Spironolactone mechanism of action
Spironolactone is a specific pharmacologic antagonist of aldosterone, acting primarily through competitive binding of receptors at the aldosterone-dependent sodium-potassium exchange site in the distal convoluted renal tubule. Spironolactone causes increased amounts of sodium and water to be excreted, while potassium is retained. Spironolactone acts both as a diuretic and as an antihypertensive drug by this mechanism. It may be given alone or with other diuretic agents which act more proximally in the renal tubule. Aldosterone interacts with a cytoplasmic mineralocorticoid receptor to enhance the expression of the Na+, K+-ATPase and the Na+ channel involved in a Na+ K+ transport in the distal tubule . Spironolactone bind to this mineralcorticoid receptor, blocking the actions of aldosterone on gene expression. Aldosterone is a hormone; its primary function is to retain sodium and excrete potassium in the kidneys.
Dosage forms of Spironolactone
G.D. Searle LLC Division of Pfizer Inc
Humans and other mammals
Indication of Spironolactone
Used primarily to treat low-renin hypertension, hypokalemia, and Conn’s syndrome.
Toxicity of Spironolactone
The oral LD sub50 /sub of spironolactone is greater than 1,000 mg/kg in mice, rats, and rabbits. Acute overdosage of spironolactone may be manifested by drowsiness, mental confusion, maculopapular or erythematous rash, nausea, vomiting, dizziness, or diarrhea. Spironolactone has been shown to be a tumorigen in chronic toxicity studies in rats.
Disclaimer: before buying a Spironolactone on prescription, consult your health care provider. Content on this page is provided for informational purposes only. Any use of this information is at your own risk.