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RX BIN: 015558
RX PCN: HT
Group ID: DDN6600
Card Holder ID: DDN6600

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2018 Price of Spironolactone

Aldactazide 25-25 tablet

$1.04

tablet

* price without discount in nearest pharmacy. Price may vary.

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Spironolactone volume of distribution

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What is Spironolactone

A potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatment of refractory edema in patients with congestive heart failure, nephrotic syndrome, or hepatic cirrhosis. Its effects on the endocrine system are utilized in the treatments of hirsutism and acne but they can lead to adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p827)

Spironolactone mechanism of action

Spironolactone is a specific pharmacologic antagonist of aldosterone, acting primarily through competitive binding of receptors at the aldosterone-dependent sodium-potassium exchange site in the distal convoluted renal tubule. Spironolactone causes increased amounts of sodium and water to be excreted, while potassium is retained. Spironolactone acts both as a diuretic and as an antihypertensive drug by this mechanism. It may be given alone or with other diuretic agents which act more proximally in the renal tubule. Aldosterone interacts with a cytoplasmic mineralocorticoid receptor to enhance the expression of the Na+, K+-ATPase and the Na+ channel involved in a Na+ K+ transport in the distal tubule . Spironolactone bind to this mineralcorticoid receptor, blocking the actions of aldosterone on gene expression. Aldosterone is a hormone; its primary function is to retain sodium and excrete potassium in the kidneys.

Dosage forms of Spironolactone

DrugDosageQuantityPrice
Spironolactone25mg100 Scored Tablet$37.00
Spironolactone50mg84 Tablet$62.00
Spironolactone100mg100 Scored Tablet$52.00
Spironolactone/Hctz25/25mg100 Scored Tablet$35.00
Spironolactone/Hctz50/50mg100 Scored Tablet$46.00
Aldactone25mg100 Tablet$42.50
Aldactone50mg100 Tablet$64.00
Aldactone100mg90 Tablet$53.00
Aldactazide25/25mg100 Tablet$49.00
Aldactazide50/50mg100 Tablet$71.00
Prescription Generics

false

International Brands

Aldactazide

Synonyms

Espironolactona Spironolactone

Manufacturers

G.D. Searle LLC Division of Pfizer Inc

CAS number

52-01-7

UNII

27O7W4T232

State

solid

Affected organisms

Humans and other mammals

Indication of Spironolactone

Used primarily to treat low-renin hypertension, hypokalemia, and Conn’s syndrome.

Toxicity of Spironolactone

The oral LD sub50 /sub of spironolactone is greater than 1,000 mg/kg in mice, rats, and rabbits. Acute overdosage of spironolactone may be manifested by drowsiness, mental confusion, maculopapular or erythematous rash, nausea, vomiting, dizziness, or diarrhea. Spironolactone has been shown to be a tumorigen in chronic toxicity studies in rats.

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