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RX BIN: 015558RX PCN: HTGroup ID: DDN6600Card Holder ID: DDN6600
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2019 Price of Zanosar

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Streptomycin volume of distribution

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What is Streptomycin

Streptomycin is an aminoglycoside antibiotic produced by the soil actinomycete Streptomyces griseus. It acts by binding to the 30S ribosomal subunit of susceptible organisms and disrupting the initiation and elongation steps in protein synthesis. It is bactericidal due to effects that are not fully understood.

Streptomycin mechanism of action

Aminoglycosides like Streptomycin “irreversibly” bind to specific 30S-subunit proteins and 16S rRNA. Specifically Streptomycin binds to four nucleotides of 16S rRNA and a single amino acid of protein S12. This interferes with decoding site in the vicinity of nucleotide 1400 in 16S rRNA of 30S subunit. This region interacts with the wobble base in the anticodon of tRNA. This leads to interference with the initiation complex, misreading of mRNA so incorrect amino acids are inserted into the polypeptide leading to nonfunctional or toxic peptides and the breakup of polysomes into nonfunctional monosomes.

Dosage forms of Streptomycin

FormRouteStrength
Injection, powder, lyophilized, for solutionintramuscular1 g/1
Powder for solutionintramuscular1 g
Liquidintramuscular; refer (see dosage form)1 g

Prescription Generics

true

International Brands

Streptomycin

Synonyms

(2-Deoxy-2-(dimethylamino)-alpha-L-glucopyranosyl)-(1-2)-(5-deoxy-3-C-formyl-alpha-L-lyxofuranosyl)-(1-4)-{n’,n”’-((1,3,5/2,4,6)-2,4,5,6-tetrahydroxycyclohexane-1,3-diyl)diguanidine} 2,4-Diguanidino-3,5,6-trihydroxycyclohexyl 5-deoxy-2-O-(2-deoxy-2-methylamino-alpha-L-glucopyranosyl)-3-C-formyl-beta-L-lyxopentanofuranoside

Manufacturers

X Gen Pharmaceuticals, Inc.

CAS number

57-92-1

UNII

Y45QSO73OB

State

solid

Affected organisms

Enteric bacteria and other eubacteria

Indication of Streptomycin

For the treatment of tuberculosis. May also be used in combination with other drugs to treat tularemia (Francisella tularensis), plague (Yersia pestis), severe M. avium complex, brucellosis, and enterococcal endocarditis (e.g. E. faecalis, E. faecium).

Toxicity of Streptomycin

Nephrotoxic and ototoxic potential. Nephrotoxicity is caused by accumulation of the drug in proximal renal tubular cells, which results in cellular damage. Tubular cells may regenerate despite continued exposure and nephrotoxicity is usually mild and reversible. Streptomycin is the least nephrotoxic of the aminoglycosides owing to the small number of cationic amino groups in its structure. Otoxocity occurs via drug accumulation in the endolymph and perilymph of the inner ear. Accumulation causes irreversible damage to hair cells of the cochlea or summit of the ampullar cristae of the vestibular complex. High frequency hearing loss precedes low frequency hearing loss. Further toxicity may result in retrograde degeneration of the auditory nerve. Vestibular toxicity may result in vertigo, nausea and vomiting, dizziness and loss of balance. LD50=430 mg/kg (Orally in rats with Streptomycin Sulfate); Side effects include nausea, vomiting, and vertigo, paresthesia of face, rash, fever, urticaria, angioneurotic edema, and eosinophilia.

RX24 Drugs Disclaimer: before buying a Streptomycin on prescription, consult your healthcare provider. Content on this page is provided for informational purposes only. Any use of this information is at your own risk.

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