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RX BIN: 015558RX PCN: HTGroup ID: DDN6600Card Holder ID: DDN6600
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2019 Price of Dsuvia

$3.92ml
price without discount in nearest pharmacy. Price may vary.

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2018 Statistics

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Discount Cards 16,000+

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Total savings $4,735,080

What is Sufentanil

An opioid analgesic that is used as an adjunct in anesthesia, in balanced anesthesia, and as a primary anesthetic agent.

Sufentanil mechanism of action

Opiate receptors are coupled with G-protein receptors and function as both positive and negative regulators of synaptic transmission via G-proteins that activate effector proteins. Binding of the opiate stimulates the exchange of GTP for GDP on the G-protein complex. As the effector system is adenylate cyclase and cAMP located at the inner surface of the plasma membrane, opioids decrease intracellular cAMP by inhibiting adenylate cyclase. Subsequently, the release of nociceptive neurotransmitters such as substance P, GABA, dopamine, acetylcholine and noradrenaline is inhibited. Opioids also inhibit the release of vasopressin, somatostatin, insulin and glucagon. Sufentanil’s analgesic activity is, most likely, due to its conversion to morphine. Opioids open calcium-dependent inwardly rectifying potassium channels (OP1 receptor agonist). This results in hyperpolarization and reduced neuronal excitability.

Dosage forms of Sufentanil

FormRouteStrength
Liquidintravenous50 mcg
Liquidintravenous; epidural50 mcg
Injectionepidural; intravenous.05 mg/mL

Prescription Generics

false

International Brands

Sufenta Inj 50mcg/ml

Synonyms

N-(4-(Methoxymethyl)-1-(2-(2-thienyl)ethyl)-4-piperidinyl)-N-phenylpropanamide N-(4-(Methoxymethyl)-1-(2-(2-thienyl)ethyl)-4-piperidyl)propionanilide

Manufacturers

Janssen Pharmaceutica, Division Of Janssen Ortho Inc.

CAS number

56030-54-7

UNII

AFE2YW0IIZ

State

solid

Affected organisms

Humans and other mammals

Indication of Sufentanil

Used as an analgesic adjunct in anesthesia and as a primary anesthetic drug in procedures requiring assisted ventilation and in the relief of pain.

Toxicity of Sufentanil

LD sub50 /sub: 18.7 mg/kg (IV in mice)

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