Save up -80% on Sufentanil
|Note: this is a drug discount program, not an insurance plan.|
|RX BIN: 015558||RX PCN: HT||Group ID: DDN6600||Card Holder ID: DDN6600|
|Pharmacists and Patients support.|
2019 Price of Dsuvia
|price without discount in nearest pharmacy. Price may vary.|
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Sufentanil volume of distribution
Discount Cards 16,000+
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Total savings $4,735,080
What is Sufentanil
An opioid analgesic that is used as an adjunct in anesthesia, in balanced anesthesia, and as a primary anesthetic agent.
Sufentanil mechanism of action
Opiate receptors are coupled with G-protein receptors and function as both positive and negative regulators of synaptic transmission via G-proteins that activate effector proteins. Binding of the opiate stimulates the exchange of GTP for GDP on the G-protein complex. As the effector system is adenylate cyclase and cAMP located at the inner surface of the plasma membrane, opioids decrease intracellular cAMP by inhibiting adenylate cyclase. Subsequently, the release of nociceptive neurotransmitters such as substance P, GABA, dopamine, acetylcholine and noradrenaline is inhibited. Opioids also inhibit the release of vasopressin, somatostatin, insulin and glucagon. Sufentanil’s analgesic activity is, most likely, due to its conversion to morphine. Opioids open calcium-dependent inwardly rectifying potassium channels (OP1 receptor agonist). This results in hyperpolarization and reduced neuronal excitability.
Dosage forms of Sufentanil
|Liquid||intravenous; epidural||50 mcg|
|Injection||epidural; intravenous||.05 mg/mL|
Sufenta Inj 50mcg/ml
Janssen Pharmaceutica, Division Of Janssen Ortho Inc.
Humans and other mammals
Indication of Sufentanil
Used as an analgesic adjunct in anesthesia and as a primary anesthetic drug in procedures requiring assisted ventilation and in the relief of pain.
Toxicity of Sufentanil
LD sub50 /sub: 18.7 mg/kg (IV in mice)
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