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RX BIN: 015558RX PCN: HTGroup ID: DDN6600Card Holder ID: DDN6600
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2019 Price of Bactrim

$6.2820 tablets/160 mg
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Sulfamethoxazole volume of distribution

The volume of distribution is approximately 1.6 L/kg for trimethoprim and approximately 0.26 L/kg for sulfamethoxazole, while the plasma protein binding reaches 37% Page 3 Bactrim ® PI 160927 3 for trimethoprim and 53% for sulfamethoxazole.

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Total savings $4,735,080

What is Sulfamethoxazole

A bacteriostatic antibacterial agent that interferes with folic acid synthesis in susceptible bacteria. Its broad spectrum of activity has been limited by the development of resistance. (From Martindale, The Extra Pharmacopoeia, 30th ed, p208)

Sulfamethoxazole mechanism of action

Sulfonamides inhibit the enzymatic conversion of pteridine and p-aminobenzoic acid (PABA) to dihydropteroic acid by competing with PABA for binding to dihydrofolate synthetase, an intermediate of tetrahydrofolic acid (THF) synthesis. THF is required for the synthesis of purines and dTMP and inhibition of its synthesis inhibits bacterial growth. Pyrimethamine and trimethoprim inhibit dihydrofolate reductase, another step in THF synthesis, and therefore act synergistically with the sulfonamides.

Dosage forms of Sulfamethoxazole

FormRouteStrength
Tabletoral500 mg
Liquidintravenous
Solutionintravenous

Prescription Generics

true

International Brands

Apo Sulfamethoxazole Tab 500mg

Synonyms

3-(p-Aminophenylsulfonamido)-5-methylisoxazole 3-Sulfanilamido-5-methylisoxazole

Manufacturers

Apotex Inc

CAS number

723-46-6

UNII

JE42381TNV

State

solid

Affected organisms

Gram negative and gram positive bacteria

Indication of Sulfamethoxazole

For the treatment bacterial infections causing bronchitis, prostatitis and urinary tract infections.

Toxicity of Sulfamethoxazole

Sulfamethoxazole may cause nausea, vomiting, diarrhea and hypersensitivity reactions. Hematologic effects such as anemia, agranulocytosis, thrombocytopenia and hemolytic anemia in patients with glucose-6-phosphate dehydrogenase deficiency may also occur. Sulfamethoxazole may displace bilirubin from albumin binding sites causing jaundice or kernicterus in newborns.

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