Save up -80% on Sulfamethoxazole
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2018 Price of Sulfamethoxazole
* price without discount in nearest pharmacy. Price may vary.
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Sulfamethoxazole volume of distribution
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Sulfamethoxazole
A bacteriostatic antibacterial agent that interferes with folic acid synthesis in susceptible bacteria. Its broad spectrum of activity has been limited by the development of resistance. (From Martindale, The Extra Pharmacopoeia, 30th ed, p208)
Sulfamethoxazole mechanism of action
Sulfonamides inhibit the enzymatic conversion of pteridine and p-aminobenzoic acid (PABA) to dihydropteroic acid by competing with PABA for binding to dihydrofolate synthetase, an intermediate of tetrahydrofolic acid (THF) synthesis. THF is required for the synthesis of purines and dTMP and inhibition of its synthesis inhibits bacterial growth. Pyrimethamine and trimethoprim inhibit dihydrofolate reductase, another step in THF synthesis, and therefore act synergistically with the sulfonamides.
Dosage forms of Sulfamethoxazole
Apo Sulfamethoxazole Tab 500mg
Gram negative and gram positive bacteria
Toxicity of Sulfamethoxazole
Sulfamethoxazole may cause nausea, vomiting, diarrhea and hypersensitivity reactions. Hematologic effects such as anemia, agranulocytosis, thrombocytopenia and hemolytic anemia in patients with glucose-6-phosphate dehydrogenase deficiency may also occur. Sulfamethoxazole may displace bilirubin from albumin binding sites causing jaundice or kernicterus in newborns.
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