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RX BIN: 015558RX PCN: HTGroup ID: DDN6600Card Holder ID: DDN6600
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2019 Price of Bactrim

$6.2820 tablets/160 mg
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Sulfamethoxazole volume of distribution

The volume of distribution is approximately 1.6 L/kg for trimethoprim and approximately 0.26 L/kg for sulfamethoxazole, while the plasma protein binding reaches 37% Page 3 Bactrim ® PI 160927 3 for trimethoprim and 53% for sulfamethoxazole.

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2018 Statistics

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Total savings $4,735,080

What is Sulfamethoxazole

A bacteriostatic antibacterial agent that interferes with folic acid synthesis in susceptible bacteria. Its broad spectrum of activity has been limited by the development of resistance. (From Martindale, The Extra Pharmacopoeia, 30th ed, p208)

Sulfamethoxazole mechanism of action

Sulfonamides inhibit the enzymatic conversion of pteridine and p-aminobenzoic acid (PABA) to dihydropteroic acid by competing with PABA for binding to dihydrofolate synthetase, an intermediate of tetrahydrofolic acid (THF) synthesis. THF is required for the synthesis of purines and dTMP and inhibition of its synthesis inhibits bacterial growth. Pyrimethamine and trimethoprim inhibit dihydrofolate reductase, another step in THF synthesis, and therefore act synergistically with the sulfonamides.

Dosage forms of Sulfamethoxazole

Tabletoral500 mg

Prescription Generics


International Brands

Apo Sulfamethoxazole Tab 500mg


3-(p-Aminophenylsulfonamido)-5-methylisoxazole 3-Sulfanilamido-5-methylisoxazole


Apotex Inc

CAS number






Affected organisms

Gram negative and gram positive bacteria

Indication of Sulfamethoxazole

For the treatment bacterial infections causing bronchitis, prostatitis and urinary tract infections.

Toxicity of Sulfamethoxazole

Sulfamethoxazole may cause nausea, vomiting, diarrhea and hypersensitivity reactions. Hematologic effects such as anemia, agranulocytosis, thrombocytopenia and hemolytic anemia in patients with glucose-6-phosphate dehydrogenase deficiency may also occur. Sulfamethoxazole may displace bilirubin from albumin binding sites causing jaundice or kernicterus in newborns.

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