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RX BIN: 015558RX PCN: HTGroup ID: DDN6600Card Holder ID: DDN6600
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2019 Price of Azulfidine

$15.14120 tablets/500 mg
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Sulfasalazine volume of distribution

The tmax and apparent volume of distribution of sulphapyridine were increased in the elderly after a single drug dosage but these differences disappeared with regular dosing. The Cmax, elimination half-life, ‘steady-state’ serum concentration, apparent volume of distribution and total clearance of sulphapyridine were all affected by acetylator status.

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What is Sulfasalazine

A drug that is used in the management of inflammatory bowel diseases. Its activity is generally considered to lie in its metabolic breakdown product, 5-aminosalicylic acid (see mesalamine) released in the colon. (From Martindale, The Extra Pharmacopoeia, 30th ed, p907)

Sulfasalazine mechanism of action

The mode of action of Sulfasalazine or its metabolites, 5-aminosalicylic acid (5-ASA) and sulfapyridine (SP), is still under investigation, but may be related to the anti-inflammatory and/or immunomodulatory properties that have been observed in animal and iin vitro/i models, to its affinity for connective tissue, and/or to the relatively high concentration it reaches in serous fluids, the liver and intestinal walls, as demonstrated in autoradiographic studies in animals. In ulcerative colitis, clinical studies utilizing rectal administration of Sulfasalazine, SP and 5-ASA have indicated that the major therapeutic action may reside in the 5-ASA moiety. The relative contribution of the parent drug and the major metabolites in rheumatoid arthritis is unknown.

Dosage forms of Sulfasalazine

FormRouteStrength
Tabletoral500 mg/1
Tablet, delayed releaseoral500 mg/1
Tablet (enteric-coated)oral500 mg

Prescription Generics

true

International Brands

Apo Sulfasalazine Tab 500mg

Synonyms

2-Hydroxy-5-((4-((2-pyridinylamino)sulfonyl)phenyl)azo)benzoic acid 2-Hydroxy-5-(4-(pyridin-2-ylsulfamoyl)-phenylazo)-benzoic acid

Manufacturers

Apotex Inc

CAS number

599-79-1

UNII

3XC8GUZ6CB

State

solid

Affected organisms

Humans and other mammals

Indication of Sulfasalazine

For the treatment of Crohn’s disease and rheumatoid arthritis as a second-line agent.

Toxicity of Sulfasalazine

Inflammation is critical for atherosclerosis development and may be a target for risk-reduction therapy. In experimental studies, activation of the inflammatory regulator, nuclear factor kappa B (NFkappaB), contributes to endothelial activation and reduced nitric oxide production. We treated patients with coronary artery disease with sulfasalazine, an inhibitor of NFkappaB, and placebo in a randomized, double-blind, crossover study design. Brachial artery flow-mediated dilation (FMD) and digital vascular function were measured at baseline and after each 6-week treatment period. Of the 53 patients enrolled in the crossover study, 32 (age 60 +/- 10, 22% female) completed all the visits, with a high rate of study withdrawal due to gastrointestinal side effects. In a subset of 10 participants, we compared the effects of 4 days of sulfasalazine treatment (n = 5) to no treatment (n = 5) on NFkappaB-regulated gene expression in peripheral blood mononuclear cells.

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