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RX BIN: 015558RX PCN: HTGroup ID: DDN6600Card Holder ID: DDN6600
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2019 Price of Anturane

$0.31tablet
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2018 Statistics

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Discount Cards 16,000+

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What is Sulfinpyrazone

A uricosuric drug that is used to reduce the serum urate levels in gout therapy. It lacks anti-inflammatory, analgesic, and diuretic properties.

Sulfinpyrazone mechanism of action

Sulfinpyrazone is an oral uricosuric agent (pyrazolone derivative) used to treat chronic or intermittent gouty arthritis. Sulfinpyrazone competitively inhibits the reabsorption of uric acid at the proximal convoluted tubule, thereby facilitating urinary excretion of uric acid and decreasing plasma urate concentrations. This is likely done through inhibition of the urate anion transporter (hURAT1) as well as the human organic anion transporter 4 (hOAT4). Sulfinpyrazone is not intended for the treatment of acute attacks because it lacks therapeutically useful analgesic and anti-inflammatory effects. Sulfinpyrazone and its sulfide metabolite possess COX inhibitory effects. Sulfinpyrazone has also been shown to be a UDP-glucuronsyltransferase inhibitor and a very potent CYP2C9 inhibitor. Sulfinpyrazone is also known to be a cystic fibrosis transmembrane conductance regulator (CFTR) inhibitor as well as an inhibitor of several multridrug resistance proteins (MRPs).

Dosage forms of Sulfinpyrazone

FormRouteStrength
Tabletoral100 mg
Tabletoral200 mg

Prescription Generics

false

International Brands

Antazone Tab 100mg

Synonyms

1,2-Diphenyl-3,5-dioxo-4-(2-phenylsulfinylethyl)pyrazolidine 1,2-Diphenyl-4-(2′-phenylsulfinethyl)-3,5-pyrazolidinedione

Manufacturers

Icn Canada Ltd.

CAS number

57-96-5

UNII

V6OFU47K3W

State

solid

Affected organisms

Humans and other mammals

Indication of Sulfinpyrazone

For the treatment of gout and gouty arthritis.

Toxicity of Sulfinpyrazone

Symptoms of overdose include nausea, vomiting, diarrhea, epigastric pain, ataxia, labored respiration, convulsions, coma. Possible symptoms, seen after overdosage with other pyrazolone derivatives: anemia, jaundice, and ulceration.

RX24 Drugs Disclaimer: consult your healthcare provider before buying a Sulfinpyrazone on prescription or using an RX manufacturer savings coupon. Content on this page is provided for informational purposes only. Any use of this information is at your own risk.

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