Save up -80% on Sulfinpyrazone
Note: this is a drug discount program, not an insurance plan.
2018 Price of Sulfinpyrazone
Apo-Sulfinpyrazone 200 mg Tablet
* price without discount in nearest pharmacy. Price may vary.
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Sulfinpyrazone volume of distribution
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
Sulfinpyrazone mechanism of action
Sulfinpyrazone is an oral uricosuric agent (pyrazolone derivative) used to treat chronic or intermittent gouty arthritis. Sulfinpyrazone competitively inhibits the reabsorption of uric acid at the proximal convoluted tubule, thereby facilitating urinary excretion of uric acid and decreasing plasma urate concentrations. This is likely done through inhibition of the urate anion transporter (hURAT1) as well as the human organic anion transporter 4 (hOAT4). Sulfinpyrazone is not intended for the treatment of acute attacks because it lacks therapeutically useful analgesic and anti-inflammatory effects. Sulfinpyrazone and its sulfide metabolite possess COX inhibitory effects. Sulfinpyrazone has also been shown to be a UDP-glucuronsyltransferase inhibitor and a very potent CYP2C9 inhibitor. Sulfinpyrazone is also known to be a cystic fibrosis transmembrane conductance regulator (CFTR) inhibitor as well as an inhibitor of several multridrug resistance proteins (MRPs).
Dosage forms of Sulfinpyrazone
Antazone Tab 100mg
Icn Canada Ltd.
Humans and other mammals
Indication of Sulfinpyrazone
For the treatment of gout and gouty arthritis.
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