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Sulfisoxazole volume of distribution
What is Sulfisoxazole
A short-acting sulfonamide antibacterial with activity against a wide range of gram- negative and gram-positive organisms. (PubChem)
Sulfisoxazole mechanism of action
Sulfisoxazole is a competitive inhibitor of the enzyme dihydropteroate synthetase. It inhibits bacterial synthesis of dihydrofolic acid by preventing the condensation of the pteridine with para-aminobenzoic acid (PABA), a substrate of the enzyme dihydropteroate synthetase. The inhibited reaction is necessary in these organisms for the synthesis of folic acid.
Dosage forms of Sulfisoxazole
|Granule, for suspension||oral|
|Powder for suspension||oral|
Apo Sulfisoxazole Tab 500mg
Enteric bacteria and other eubacteria
Indication of Sulfisoxazole
For the treatment of severe, repeated, or long-lasting urinary tract infections, meningococcal meningitis, acute otitis media, trachoma, inclusion conjunctivitis, nocardiosis, chancroid, toxoplasmosis, malaria and other bacterial infections.
Toxicity of Sulfisoxazole
LD sub 50 /sub =6800 mg/kg (Orally in mice)
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