Save up -80% on Sumatriptan
Note: this is a drug discount program, not an insurance plan.
2018 Price of Sumatriptan
Sumatriptan succ 100 mg tablet
* price without discount in nearest pharmacy. Price may vary.
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Sumatriptan volume of distribution
* 2.7 L/kg (subcutaneous dosing)
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Sumatriptan
A serotonin agonist that acts selectively at 5HT1 receptors. It is used in the treatment of migraine disorders. A transdermal patch version of sumatriptan is currently in phase I trials in the U.S. under the code name NP101 (NuPathe).
Sumatriptan mechanism of action
The 5-HT sub1B /sub and 5-HT sub1D /sub receptors function as autoreceptors, which inhibit the firing of serotonin neurons and a reduction in the synthesis and release of serotonin upon activation. After sumatriptan binds to these receptors, adenylate cyclase activity is inhibited via regulatory G proteins, incrases intracellular calcium, and affects other intracellular events. This results in vasoconstriction and inhibtion of sensory nociceptive (trigeminal) nerve firing and vasoactive neuropeptide release.
Dosage forms of Sumatriptan
Actavis Pharma Company
Humans and other mammals
Indication of Sumatriptan
For the treatment of migraine attacks with or without aura.
Toxicity of Sumatriptan
Symptoms of overdose include convulsions, tremor, paralysis, inactivity, ptosis, erythema of the extremities, abnormal respiration, cyanosis, ataxia, mydriasis, salivation, and lacrimation.
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