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RX BIN: 015558RX PCN: HTGroup ID: DDN6600Card Holder ID: DDN6600
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2019 Price of Belsomra

$354.2030 tablets/20 mg
price without discount in nearest pharmacy. Price may vary.

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Suvorexant volume of distribution

The mean volume of distribution of suvorexant is approximately 49 liters. Suvorexant is extensively bound (>99%) to human plasma proteins and does not preferentially distribute into red blood cells.

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2018 Statistics

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Discount Cards 16,000+

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Clients Benefit 29%

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Total savings $4,735,080

What is Suvorexant

Suvorexant is a selective dual antagonist of orexin receptors OX1R and OX2R that promotes sleep by reducing wakefulness and arousal. It has been approved for the treatment of insomnia.

Suvorexant mechanism of action

Suvorexant is a dual antagonist of orexin receptors OX1R and OX2R. It exerts its pharmacological effect by inhibiting binding of neuropeptides orexin A and B, also known as hypocretin 1 and 2, that are produced by neurons in the lateral hypothalamus. These neurons control the wake-promoting centers of the brain and are active during wakefulness, especially during motor activities, and stop firing during sleep. By inhibiting the reinforcement of arousal systems, suvorexant use causes a decrease in arousal and wakefulness, rather than having a direct sleep-promoting effect.

Dosage forms of Suvorexant

DrugDosageQuantityPrice
Belsomra5mg7 tabletes$84
Belsomra10mg20 tabletes$234
Belsomra15mg30 tabletes$346
Belsomra20mg90 tabletes$989

Prescription Generics

false

International Brands

Belsomra

Synonyms

[(7R)-4-(5-Chlor-1,3-benzoxazol-2-yl)-7-methyl-1,4-diazepan-1-yl][5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl]methanon[(7R)-4-(5-chloro-1,3-benzoxazol-2-yl)-7-methyl-1,4-diazepan-1-yl][5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl]methanone

Manufacturers

Merck Sharp – Dohme Corp.

CAS number

1030377-33-3

UNII

081L192FO9

State

solid

Affected organisms

Indication of Suvorexant

Suvorexant is indicated for the treatment of insomnia characterized by difficulties with sleep onset and/or sleep maintenance.

Toxicity of Suvorexant

Dose-related somnolence and CNS depression are the most common adverse effects associated with the use of suvorexant. It has also been shown to impair driving skills and may increase the risk of falling asleep while driving. Next-day impairments are found to be highest if suvorexant is taken with less than a full night of sleep remaining, with higher doses, or if co-administered with other CNS depressants or CYP3A inhibitors. Complex behaviours such as sleep driving, preparing and eating food, and making phone calls have been reported in association with the use of hypnotics such as suvorexant. A dose-dependant increase in suicidal ideation has been observed, especially in patients with a previous diagnosis of depression. Sleep paralysis, hypnagogic/hypnopompic hallucinations including vivid and disturbing perceptions, and mild cataplexy have also been reported. There are no adequate studies in pregnant women to ensure its safety during pregnancy or breast feeding.

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What is Belsomra?

Belsomra is a sleeping pill of a new generation, the only drug that does not cause sleep, but “blocks wakefulness.” In contrast to previously known hypnotic drugs, Belsomra has practically no contraindications (except for the rare disease narcolepsy) and side effects. The drug has been developed by pharmacists relatively recently, but has already been recognized by doctors as an effective and safe means. With suvoreksant you can gain a healthy and high-quality sleep, without suffering later daytime sleepiness or headaches.

The drug Belsomra developed on the basis of modern research in the field of sleep. The principle of operation of suvorexant is the effect on orexin receptors: a protein neurotransmitter that ensures the process of wakefulness. OX1 and OX2 are orexin receptors, the blocking of which ensures the rapid onset and maintenance of all phases of sleep without exerting a retarding effect on the central nervous system.

Thus, the mechanism of action of the drug suvorexant provides for blocking wakefulness, which significantly distinguishes it from all the drugs already on the market to combat sleep disorders that provoke the onset of sleep. Acceptance of suvorexant in the minimum dose allows not only to improve the quality of sleep, but also to increase the rate of its onset by 40%.

Most of the hypnotic drugs cause pronounced muscle relaxation, which is the reason for the cessation of breathing in sleep and is unacceptable for patients with neurological, endocrine, and pulmonary diseases. The peculiarities of the preparation Belsomra, which allow it not to exert a depressant effect on the respiratory center, make it possible to apply this soporific in patients suffering from obstructive sleep apnea and chronic nocturnal hypoxemia.