Save up -80% on Tadalafil
Note: this is a drug discount program, not an insurance plan.
2018 Price of Tadalafil
Cialis 2.5 mg tablet
* price without discount in nearest pharmacy. Price may vary.
We offer free Tadalafil coupons and discounts that may help you save up to 80% off the retail price in your local pharmacy. Just print your coupon! It’s ready to use and never expire. Present your discount card in most local pharmacies to get a discount on Tadalafil every time. What are you waiting for? Claim your prescription drug card now!
Tadalafil volume of distribution
|Adcirca||Tablet||20 mg/1||Oral||Avera Mc Kennan Hospital|
|Adcirca||Tablet||20 mg/1||Oral||United Therapeutics|
|Adcirca||Tablet||20 mg/1||Oral||Aphena Pharma Solutions Tennessee, Inc.|
|Cialis||Tablet, film coated||5 mg/1||Oral||Cardinal Health|
|Cialis||Tablet, film coated||10 mg/1||Oral||Eli Lilly & Co. Ltd.|
|Cialis||Tablet, film coated||20 mg/1||Oral||Rebel Distributors|
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Tadalafil
Tadalafil is an orally adminstered drug used to treat male erectile dysfunction (impotence). It is marketed worldwide under the brand name Cialis. It is a phosphodiesterase 5 (PDE5) inhibitor. Tadalafil’s distinguishing pharmacologic feature is its longer half-life (17.5 hours) compared with Viagra and Levitra (4-5 hours). This longer half-life results in a longer duration of action and is, in part, responsible for the Cialis nickname of the “weekend pill.” This longer half-life also is the basis of current investigation for tadalafil’s use in pulmonary arterial hypertension as a once-daily therapy. (Wikipedia)
Tadalafil mechanism of action
Tadalafil inhibits the cGMP specific phosphodiesterase type 5 (PDE5) which is responsible for degradation of cGMP in the corpus cavernosum located around the penis. Penile erection during sexual stimulation is caused by increased penile blood flow resulting from the relaxation of penile arteries and corpus cavernosal smooth muscle. This response is mediated by the release of nitric oxide (NO) from nerve terminals and endothelial cells, which stimulates the synthesis of cGMP in smooth muscle cells. Cyclic GMP causes smooth muscle relaxation and increased blood flow into the corpus cavernosum. The inhibition of phosphodiesterase type 5 (PDE5) by tadalafil enhances erectile function by increasing the amount of cGMP.
Dosage forms of Tadalafil
Apo-tadalafil, Dom-tadalafil, Ipg-tadalafil, Jamp-tadalafil, Mar-tadalafil, Mint-tadalafil, Mylan-tadalafil, PMS-tadalafil, Priva-tadalafil, Ran-tadalafil, Riva-tadalafil, Tadalafil Mylan, Teva-tadalafil
Act Tadalafil, Adcirca, Cialis, Tadalafil, Tadalafil Mylan, Teva-tadalafil
Actavis Pharma Company, Aphena Pharma Solutions Tennessee, Avera Mc Kennan Hospital, Bryant ranch prepack, Cardinal Health, Dispensing Solutions, Eli Lilly & Co., Eli Lilly Nederland B.V., Pd Rx Pharmaceuticals, Physicians Total Care, Pro Doc Limitee, Rebel Distributors, Sanis Health Inc, International Pharmaceutical Generics, Teva
Humans and other mammals
Indication of Tadalafil
Used for the treatment of erectile dysfunction.
Toxicity of Tadalafil
Oral, Rat LDsub50/sub = 2000 mg/kg, no deaths or toxicity.
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