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RX BIN: 015558
RX PCN: HT
Group ID: DDN6600
Card Holder ID: DDN6600

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2018 Price of Tadalafil

Cialis 2.5 mg tablet

$4.76

tablet

* price without discount in nearest pharmacy. Price may vary.

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Tadalafil volume of distribution

NameDosageStrengthRouteLabeller
AdcircaTablet20 mg/1OralAvera Mc Kennan Hospital
AdcircaTablet20 mg/1OralUnited Therapeutics
AdcircaTablet20 mg/1OralAphena Pharma Solutions Tennessee, Inc.
CialisTablet, film coated5 mg/1OralCardinal Health
CialisTablet, film coated10 mg/1OralEli Lilly & Co. Ltd.
CialisTablet, film coated20 mg/1OralRebel Distributors

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What is Tadalafil

Tadalafil is an orally adminstered drug used to treat male erectile dysfunction (impotence). It is marketed worldwide under the brand name Cialis. It is a phosphodiesterase 5 (PDE5) inhibitor. Tadalafil’s distinguishing pharmacologic feature is its longer half-life (17.5 hours) compared with Viagra and Levitra (4-5 hours). This longer half-life results in a longer duration of action and is, in part, responsible for the Cialis nickname of the “weekend pill.” This longer half-life also is the basis of current investigation for tadalafil’s use in pulmonary arterial hypertension as a once-daily therapy. (Wikipedia)

Tadalafil mechanism of action

Tadalafil inhibits the cGMP specific phosphodiesterase type 5 (PDE5) which is responsible for degradation of cGMP in the corpus cavernosum located around the penis. Penile erection during sexual stimulation is caused by increased penile blood flow resulting from the relaxation of penile arteries and corpus cavernosal smooth muscle. This response is mediated by the release of nitric oxide (NO) from nerve terminals and endothelial cells, which stimulates the synthesis of cGMP in smooth muscle cells. Cyclic GMP causes smooth muscle relaxation and increased blood flow into the corpus cavernosum. The inhibition of phosphodiesterase type 5 (PDE5) by tadalafil enhances erectile function by increasing the amount of cGMP.

Dosage forms of Tadalafil

DrugDosageQuantityPrice
Tadalafil5mg90 Tablet$60.90
Tadalafil10mg24 Tablet$22.55
Tadalafil10mg40 Tablet$32.45
Tadalafil20mg16 Tablet$21.90
Tadalafil20mg88 Tablet$67.60
Tadalafil2.5mg28 Tablet$33.00
Cialis5mg84 Tablet$261.50
Cialis10mg32 Tablet$435.00
Cialis20mg4 Tablet$56.00
Cialis20mg12 Tablet$136.85
Adcirca20mg56 Tablet$1,100.00
Prescription Generics

Apo-tadalafil, Dom-tadalafil, Ipg-tadalafil, Jamp-tadalafil, Mar-tadalafil, Mint-tadalafil, Mylan-tadalafil, PMS-tadalafil, Priva-tadalafil, Ran-tadalafil, Riva-tadalafil, Tadalafil Mylan, Teva-tadalafil

International Brands

Act Tadalafil

Synonyms

Act Tadalafil, Adcirca, Cialis, Tadalafil, Tadalafil Mylan, Teva-tadalafil

Manufacturers

Actavis Pharma Company, Aphena Pharma Solutions Tennessee, Avera Mc Kennan Hospital, Bryant ranch prepack, Cardinal Health, Dispensing Solutions, Eli Lilly & Co., Eli Lilly Nederland B.V., Pd Rx Pharmaceuticals, Physicians Total Care, Pro Doc Limitee, Rebel Distributors, Sanis Health Inc, International Pharmaceutical Generics, Teva

CAS number

171596-29-5

UNII

742SXX0ICT

State

solid

Affected organisms

Humans and other mammals

Indication of Tadalafil

Used for the treatment of erectile dysfunction.

Toxicity of Tadalafil

Oral, Rat LDsub50/sub = 2000 mg/kg, no deaths or toxicity.

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