Save up -80% on Tamoxifen
|Note: this is a drug discount program, not an insurance plan.|
|RX BIN: 015558||RX PCN: HT||Group ID: DDN6600||Card Holder ID: DDN6600|
|Pharmacists and Patients support.|
2019 Price of Nolvadex
|$19.89||30 tablets/20 mg|
|price without discount in nearest pharmacy. Price may vary.|
We offer free Tamoxifen coupons and discounts that may help you save up to 80% off the retail price in your local pharmacy. Just print your coupon! It’s ready to use and never expire. Present your manufacturer copay card in most local pharmacies to get a discount on Tamoxifen every time. What are you waiting for? Claim your prescription drug card now!
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Tamoxifen volume of distribution
The volume of distribution is 50-60 l/kg
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Tamoxifen
One of the selective estrogen receptor modulators (SERM) with tissue-specific activities for the treatment and prevention of estrogen receptor positive breast cancer. Tamoxifen acts as an anti-estrogen (inhibiting agent) in the mammary tissue, but as an estrogen (stimulating agent) in cholesterol metabolism, bone density, and cell proliferation in the endometrium.
Tamoxifen mechanism of action
Tamoxifen is a nonsteroidal agent that binds to estrogen receptors (ER), inducing a conformational change in the receptor. This results in a blockage or change in the expression of estrogen dependent genes. The prolonged binding of tamoxifen to the nuclear chromatin of these results in reduced DNA polymerase activity, impaired thymidine utilization, blockade of estradiol uptake, and decreased estrogen response. It is likely that tamoxifen interacts with other coactivators or corepressors in the tissue and binds with different estrogen receptors, ER-alpha or ER-beta, producing both estrogenic and antiestrogenic effects.
Dosage forms of Tamoxifen
Apo-tamox Tab 10mg
Humans and other mammals
Indication of Tamoxifen
Tamoxifen is indicated for the treatment of metastatic breast cancer in women and men and ductal carcinoma in Situ.
Toxicity of Tamoxifen
Signs observed at the highest doses following studies to determine LD sub50 /sub in animals were respiratory difficulties and convulsions.
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