Save up -80% on Tamoxifen

Note: this is a drug discount program, not an insurance plan.

RX BIN: 015558
RX PCN: HT
Group ID: DDN6600
Card Holder ID: DDN6600

Pharmacists and Patients support.

2018 Price of Tamoxifen

Tamoxifen 10 mg tablet

$1.89

tablet

* price without discount in nearest pharmacy. Price may vary.

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Tamoxifen volume of distribution

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What is Tamoxifen

One of the selective estrogen receptor modulators (SERM) with tissue-specific activities for the treatment and prevention of estrogen receptor positive breast cancer. Tamoxifen acts as an anti-estrogen (inhibiting agent) in the mammary tissue, but as an estrogen (stimulating agent) in cholesterol metabolism, bone density, and cell proliferation in the endometrium.

Tamoxifen mechanism of action

Tamoxifen is a nonsteroidal agent that binds to estrogen receptors (ER), inducing a conformational change in the receptor. This results in a blockage or change in the expression of estrogen dependent genes. The prolonged binding of tamoxifen to the nuclear chromatin of these results in reduced DNA polymerase activity, impaired thymidine utilization, blockade of estradiol uptake, and decreased estrogen response. It is likely that tamoxifen interacts with other coactivators or corepressors in the tissue and binds with different estrogen receptors, ER-alpha or ER-beta, producing both estrogenic and antiestrogenic effects.

Dosage forms of Tamoxifen

FormRouteStrength
Tabletoral10 mg
Tabletoral20 mg
Liquidoral10 mg/5mL
Prescription Generics

true

International Brands

Apo-tamox Tab 10mg

Synonyms

(Z)-2-(4-(1,2-Diphenyl-1-butenyl)phenoxy)-N,N-dimethylethanamine (Z)-2-(Para-(1,2-diphenyl-1-butenyl)phenoxy)-N,N-dimethylamine

Manufacturers

Apotex Inc

CAS number

10540-29-1

UNII

094ZI81Y45

State

solid

Affected organisms

Humans and other mammals

Indication of Tamoxifen

Tamoxifen is indicated for the treatment of metastatic breast cancer in women and men and ductal carcinoma in Situ.

Toxicity of Tamoxifen

Signs observed at the highest doses following studies to determine LD sub50 /sub in animals were respiratory difficulties and convulsions.

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