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RX BIN: 015558
RX PCN: HT
Group ID: DDN6600
Card Holder ID: DDN6600

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2018 Price of Tamsulosin

Tamsulosin hcl 0.4 mg capsule

$4.3

capsule

* price without discount in nearest pharmacy. Price may vary.

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Tamsulosin volume of distribution

* 16 L (intravenous administration to ten healthy male adults)

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What is Tamsulosin

Tamsulosin is a selective antagonist at alpha-1A and alpha-1B-adrenoceptors in the prostate, prostatic capsule, prostatic urethra, and bladder neck. At least three discrete alpha1-adrenoceptor subtypes have been identified: alpha-1A, alpha-1B and alpha-1D; their distribution differs between human organs and tissue. Approximately 70% of the alpha1-receptors in human prostate are of the alpha-1A subtype. Blockage of these receptors causes relaxation of smooth muscles in the bladder neck and prostate.

Tamsulosin mechanism of action

Tamsulosin is a selective antagonist at alpha-1A and alpha-1B-adrenoceptors in the prostate, prostatic capsule, prostatic urethra, and bladder neck. At least three discrete alpha1-adrenoceptor subtypes have been identified: alpha-1A, alpha-1B and alpha-1D; their distribution differs between human organs and tissue. Approximately 70% of the alpha1-receptors in human prostate are of the alpha-1A subtype. Blockage of these receptors causes relaxation of smooth muscles in the bladder neck and prostate, and thus decreases urinary outflow resistance in men.

Dosage forms of Tamsulosin

FormRouteStrength
Tablet (extended-release)oral0.4 mg
Capsuleoral
Capsule (immediate and extended release)oral
Prescription Generics

true

International Brands

Apo-tamsulosin CR

Synonyms

(R)-5-(2-((2-(2-Ethoxyphenoxy)ethyl)amino)propyl)-2-methoxybenzenesulfonamide 5-(2-(2-(2-Ethoxyphenoxy)ethylamino)propyl)-2-methoxy-benzenesulfonamide

Manufacturers

Apotex Inc

CAS number

106133-20-4

UNII

G3P28OML5I

State

solid

Affected organisms

Humans and other mammals

Indication of Tamsulosin

Used in the treatment of signs and symptoms of benign prostatic hyperplasia (reduction in urinary obstruction and relief of associated manifestations such as hesitancy, terminal dribbling of urine, interrupted or weak stream…etc.)

Toxicity of Tamsulosin

LD sub50 /sub = 650 mg/kg (in rats)

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