Save up -80% on Tazarotene
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2018 Price of Tazarotene
Tazorac 0.05 % Gel
* price without discount in nearest pharmacy. Price may vary.
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Tazarotene volume of distribution
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Tazarotene
Tazarotene (marketed as Tazorac, Avage and Zorac) is a prescription topical retinoid sold as a cream or gel. This medication is approved for treatment of psoriasis, acne, and sun damaged skin (photodamage). (Wikipedia)
Tazarotene mechanism of action
Although the exact mechanism of tazarotene action is not known, studies have shown that the active form of the drug (tazarotenic acid) binds to all three members of the retinoic acid receptor (RAR) family: RARa, RARb, and RARg, but shows relative selectivity for RARb, and RARg and may modify gene expression. It also has affinity for RXR receptors.
Dosage forms of Tazarotene
|Aerosol, foam||topical||1 mg/g|
Humans and other mammals
Indication of Tazarotene
Used to treat psoriasis, acne and sun damaged skin (photodamage).
Toxicity of Tazarotene
Excessive topical use may lead to marked redness, peeling, or discomfort. Oral ingestion of the drug may affect liver function causing hypertriglyceridemia. Other symptoms may include conjunctival irritation, hair loss, headache, edema, fatigue, dermatitis, nausea, and visual disturbances. Oral administration of this material to rats and rabbits at doses of 0.20 mg/kg/day (rabbits) and 0.25 mg/kg/day (rats) resulted in developmental toxicity. A no effect level of 0.05 mg/kg/day was established. Similar teratogenic effects have been reported for other retinoid compounds.
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