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RX BIN: 015558
RX PCN: HT
Group ID: DDN6600
Card Holder ID: DDN6600

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2018 Price of Technetium Tc-99m sestamibi

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Technetium Tc-99m sestamibi volume of distribution

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What is Technetium Tc-99m sestamibi

Technetium Tc-99m sestamibi (commonly sestamibi) is a pharmaceutical agent used in nuclear medicine imaging. The drug is a coordination complex consisting of the radioisotope technetium-99m bound to six (sesta=6) methoxyisobutylisonitrile (MIBI) ligands. Following intravenous injection of the drug, Technetium Tc-99m sestamibi is taken up by the myocardium, parathyroid, and/or breast tissue. The mechanism by which sestamibi localizes to these tissues has not been established. Single photon emission computed tomography (SPECT) is then performed to detect the gamma ray emmitted by the decay of Technetium-99m to Technetium-99. Currently available within a preparation kit for injection, Technetium Tc 99m Sestamibi is indicated for: 1) detecting coronary artery disease by localizing myocardial ischemia (reversible defects) and infarction (non-reversible defects); and 2) evaluating myocardial function and developing information for use in patient management decisions.

Technetium Tc-99m sestamibi mechanism of action

Dosage forms of Technetium Tc-99m sestamibi

FormRouteStrength
Injection, powder, lyophilized, for solutionintravenous1 mg/mL
Injectionintravenous1 mg/10mL
Injection, powder, lyophilized, for solutionparenteral1 mg/5mL
Prescription Generics

false

International Brands

Cardiolite

Synonyms

99m Tc-sestamibi 99m-Tc sestamibi

Manufacturers

Lantheus Medical Imaging, Inc.

CAS number

109581-73-9

UNII

971Z4W1S09

State

solid

Affected organisms

Indication of Technetium Tc-99m sestamibi

Technetium Tc 99m Sestamibi is indicated for: 1) detecting coronary artery disease by localizing myocardial ischemia (reversible defects) and infarction (non-reversible defects); and 2) evaluating myocardial function and developing information for use in patient management decisions.

Toxicity of Technetium Tc-99m sestamibi

The following adverse reactions have been reported in 0.5% of patients: signs and symptoms consistent with seizure occurring shortly after administration of the agent; transient arthritis; angioedema, arrhythmia, dizziness, syncope, abdominal pain, vomiting, and severe hypersensitivity characterized by dyspnea, hypotension, bradycardia, asthenia, and vomiting within two hours after a second injection of Technetium Tc 99m Sestamibi. A few cases of flushing, edema, injection site inflammation, dry mouth, fever, pruritis, rash, urticaria and fatigue have also been attributed to administration of the agent.

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