Save up -80% on Telaprevir
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2018 Price of Telaprevir
* price without discount in nearest pharmacy. Price may vary.
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Telaprevir volume of distribution
Apparent volume of distribution (Vd/F) = 252 L. This large volume of distribution suggests extensive penetration into tissues.
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Telaprevir
Telaprevir (VX-950) is a highly selective and potent inhibitor of the HCV NS3-4A serine protease. It is a member of a class of antiviral drugs known as protease inhibitors and is the first hepatitis C drug that has demonstrated activity in patients who have failed prior therapy. On April 28, 2011, the FDA Antiviral Drugs Advisory Committee voted 18-0 to recommend approval telaprevir for people with genotype 1 chronic hepatitis C and was approved in the U.S. in May, 2011.
Telaprevir mechanism of action
Telaprevir is an inhibitor of the HCV NS3/4A serine protease, necessary for the proteolytic cleavage of the HCV encoded polyprotein into mature forms of the NS4A, NS4B, NS5A and NS5B proteins and essential for viral replication. It belongs to the chemical class of alpha-ketoamids and binds to NS3/4A in a covalent but reversible manner.
Dosage forms of Telaprevir
|Film-coated tablet||Oral use||375 mg|
Vertex Pharmaceuticals (Canada) Incorporated
Hepatitis C virus, RSV and other RNA/DNA viruses
Indication of Telaprevir
Treating chronic hepatitis C virus (genotype 1) infection in patients with compensated liver (due to liver diseases like cirrhosis) that are treatment naive or have failed therapy with interferons (either null or partial responders and treatment relapsers).
Toxicity of Telaprevir
The highest documented dose administered is 1875 mg every 8 hours for 4 days in healthy subjects with telaprevir alone. In that study, the following common adverse events were reported more frequently with the 1875 mg q8h regimen compared to the 750 mg q8h regimen: nausea, headache, diarrhea, decreased appetite, dysgeusia, and vomiting. The two most common adverse events that caused the discontinuation of treatment are anemia and rash.
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