Save up -80% on Tenecteplase
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Price of Tenecteplase
Tnkase 50 mg kit
* price without discount in nearest pharmacy. Price may vary.
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Tenecteplase volume of distribution
What is Tenecteplase
Tissue plasminogen activator (tPA). Tenecteplase is a 527 amino acid glycoprotein developed by introducing the following modifications to the complementary DNA (cDNA) for natural human tPA: a substitution of threonine 103 with asparagine, and a substitution of asparagine 117 with glutamine, both within the kringle 1 domain, and a tetra-alanine substitution at amino acids 296-299 in the protease domain.
Tenecteplase mechanism of action
Tenecteplase binds to fibrin rich clots via the fibronectin finger-like domain and the Kringle 2 domain. The protease domain then cleaves the Arg/Val bond in plasminogen to form plasmin. Plasmin in turn degrades the fibrin matrix of the thrombus, thereby exerting its thrombolytic action.
Dosage forms of Tenecteplase
|Powder and solvent for solution for injection||Intravenous use||10000 units|
|Powder and solvent for solution for injection||Intravenous use||8000 units|
Hoffmann La Roche Limited
Humans and other mammals
Indication of Tenecteplase
For treatment of myocardial infarction and lysis of intracoronary emboli
Toxicity of Tenecteplase
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