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RX BIN: 015558
RX PCN: HT
Group ID: DDN6600
Card Holder ID: DDN6600

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2018 Price of Teniposide

Vumon 10 mg/ml ampul

$75.31

ml

* price without discount in nearest pharmacy. Price may vary.

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Teniposide volume of distribution

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What is Teniposide

A semisynthetic derivative of podophyllotoxin that exhibits antitumor activity. Teniposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent cells from entering into the mitotic phase of the cell cycle, and lead to cell death. Teniposide acts primarily in the G2 and S phases of the cycle.

Teniposide mechanism of action

The mechanism of action appears to be related to the inhibition of type II topoisomerase activity since teniposide does not intercalate into DNA or bind strongly to DNA. Teniposide binds to and inhibits DNA topoisomerase II. The cytotoxic effects of teniposide are related to the relative number of double-stranded DNA breaks produced in cells, which are a reflection of the stabilization of a topoisomerase II-DNA intermediate.

Dosage forms of Teniposide

FormRouteStrength
Injection, solutionintravenous10 mg/mL
Liquidintravenous10 mg
Prescription Generics

false

International Brands

Teniposide

Synonyms

4′-demethylepipodophyllotoxin 9-(4,6-O-(R)-2-thenylidene-beta-D-glucopyranoside) Epidophyllotoxin

Manufacturers

WG Critical Care, LLC

CAS number

29767-20-2

UNII

957E6438QA

State

solid

Affected organisms

Humans and other mammals

Indication of Teniposide

Teniposide is used for the treatment of refractory acute lymphoblastic leukaemia

Toxicity of Teniposide

RX24 Drugs Disclaimer: before buying a Teniposide on prescription, consult your healthcare provider. Content on this page is provided for informational purposes only. Any use of this information is at your own risk.

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