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Price of Teniposide
Vumon 10 mg/ml ampul
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Teniposide volume of distribution
What is Teniposide
A semisynthetic derivative of podophyllotoxin that exhibits antitumor activity. Teniposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent cells from entering into the mitotic phase of the cell cycle, and lead to cell death. Teniposide acts primarily in the G2 and S phases of the cycle. (PubChem)
Teniposide mechanism of action
The mechanism of action appears to be related to the inhibition of type II topoisomerase activity since teniposide does not intercalate into DNA or bind strongly to DNA. Teniposide binds to and inhibits DNA topoisomerase II. The cytotoxic effects of teniposide are related to the relative number of double-stranded DNA breaks produced in cells, which are a reflection of the stabilization of a topoisomerase II-DNA intermediate.
Dosage forms of Teniposide
|Injection, solution||intravenous||10 mg/mL|
WG Critical Care, LLC
Humans and other mammals
Indication of Teniposide
Teniposide is used for the treatment of refractory acute lymphoblastic leukaemia
Toxicity of Teniposide
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