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RX BIN: 015558
RX PCN: HT
Group ID: DDN6600
Card Holder ID: DDN6600

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2018 Price of Terazosin

Hytrin 5 mg Tablet

$1.26

tablet

* price without discount in nearest pharmacy. Price may vary.

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What is Terazosin

Terazosin is a selective alpha1-antagonist used for treatment of symptoms of benign prostatic hyperplasia (BPH). It also acts to lower blood pressure, so it is a drug of choice for men with hypertension and prostate enlargement. It works by blocking the action of adrenaline on smooth muscle of the bladder and the blood vessel walls.

Terazosin mechanism of action

In general, alpha; sub1 /sub-adrenergic receptors mediate contraction and hypertrophic growth of smooth muscle cells. alpha; sub1 /sub-Receptors are 7-transmembrane domain receptors coupled to G proteins, G subq/11 /sub. Three alpha; sub1 /sub-receptor subtypes, which share approximately 75% homology in their transmembrane domains, have been identified: alpha; sub1A /sub (chromosome 8), alpha; sub1B /sub (chromosome 5), and alpha; sub1D /sub (chromosome 20). Terazosin is the first alpha; sub1 /sub-receptor antagonist to demonstrate selectivity for the alpha; sub1A /sub-receptor. All three receptor subtypes appear to be involved in maintaining vascular tone. The alpha; sub1A /sub-receptor maintains basal vascular tone while the alpha; sub1B /sub-receptor mediates the vasocontrictory effects of exogenous alpha; sub1 /sub-agonists. Activation of alpha; sub1 /sub-receptors activates G subq /sub-proteins, which results in intracellular stimulation of phospholipases C, A sub2 /sub, and D. This results in mobilization of Ca sup2+ /sup from intracellular stores, activation of mitogen-activated kinase and PI sub3 /sub kinase pathways and subsequent vasoconstriction. Terozosin produces its pharmacological effects by inhibiting alpha; sub1A /sub-receptor activation. Inhibition of these receptors in the vasculature and prostate results in muscle relaxation, decreased blood pressure and improved urinary outflow in symptomatic benign prostatic hyperplasia.

Dosage forms of Terazosin

DrugDosageQuantityPrice
Terazosin1mg100 Tablet$62.50
Hytrin2mg84 Tablet$75.00
Hytrin5mg90 Tablet$82.00
Prescription Generics

true

International Brands

Apo-terazosin

Synonyms

1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-((tetrahydro-2-furanyl)carbonyl)piperazine Terazosin

Manufacturers

Apotex Inc

CAS number

63590-64-7

UNII

8L5014XET7

State

solid

Affected organisms

Humans and other mammals

Indication of Terazosin

For the treatment of symptomatic BPH and mild to moderate hypertension.

Toxicity of Terazosin

LD sub50 /sub=259.3mg/kg (IV in mice)

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