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2018 Price of Terbutaline
Terbutaline sulf 1 mg/ml vial
* price without discount in nearest pharmacy. Price may vary.
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Terbutaline volume of distribution
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Terbutaline
A selective beta-2 adrenergic agonist used as a bronchodilator and tocolytic.
Terbutaline mechanism of action
The pharmacologic effects of terbutaline are at least in part attributable to stimulation through beta-adrenergic receptors of intracellular adenyl cyclase, the enzyme that catalyzes the conversion of adenosine triphosphate (ATP) to cyclic- 3′,5′- adenosine monophosphate (c-AMP). Increased c-AMP levels are associated with relaxation of bronchial smooth muscle and inhibition of release of mediators of immediate hypersensitivity from cells, especially from mast cells.
Dosage forms of Terbutaline
|Powder (metered dose)||inhalation||0.5 mg|
Bricanyl Tab 2.5 mg
Astrazeneca Canada Inc
Humans and other mammals
Indication of Terbutaline
For the prevention and reversal of bronchospasm in patients 12 years of age and older with reversible, obstructive airway disease, as well as symptomatic management of reversible bronchospasm associated with bronchitis and emphysema. Also used acute IV and sub-Q therapy in selected women to inhibit uterine contractions in preterm labor (tocolysis) and prolong gestation when beneficial.
Toxicity of Terbutaline
Terbutaline Sulfate: Oral LDsub50/sub(rat) = 8.7 g/kg; Oral LDsub50/sub(mouse) = 205 mg/kg; Oral LDsub50/sub(dog) = 1.5 g/kg; IP LDsub50/sub(rat)= 220 mg/kg ; IP LDsub50/sub(mouse) = 130 mg/kg; Oral LDsub50/sub(rabbit) = 8 g/kg; IV LDsub50/sub(mouse) = 36 mg/kg; IV LDsub50/sub(dog) = 116 mg/kg; IV LDsub50/sub(rabbit) = 110 mg/kg
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