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RX BIN: 015558
RX PCN: HT
Group ID: DDN6600
Card Holder ID: DDN6600

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2018 Price of Teriflunomide

$

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Teriflunomide volume of distribution

After a single intravenous dose, the volume of distribution is 11 L.

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What is Teriflunomide

Teriflunomide is the active metabolite of leflunomide, and it acts as an immunomodulatory agent by inhibiting pyrimidine synthesis. It is marketed under the name Aubagio and is indicated for the treatment of multiple sclerosis, specifically relapsing forms. The FDA label states an important warning about the risk of hepatoxicity and teratogenicity for patients using teriflunomide.

Teriflunomide mechanism of action

The exact mechanism by which teriflunomide acts in MS is not known. What is known is that teriflunomide prevents pyrimidine synthesis by inhibiting the mitochondrial enzyme dihydroorotate dehydrogenase, and this may be involved in its immunomodulatory effect in MS.

Dosage forms of Teriflunomide

FormRouteStrength
Film-coated tabletOral use14 mg
Tabletoral14 mg
Tablet, film coatedoral14 mg/1
Prescription Generics

false

International Brands

Aubagio

Synonyms

(Z)-2-Cyano-alpha,alpha,alpha-trifluoro-3-hydroxy-P-crotonotoluidide a 77-1726

Manufacturers

Genzyme Corp.

CAS number

163451-81-8

UNII

1C058IKG3B

State

solid

Affected organisms

Humans and other mammals

Indication of Teriflunomide

Used in the treatment of relapsing forms of multiple sclerosis (MS).

Toxicity of Teriflunomide

Teriflunomide is contraindicated in pregnant women or women of childbearing age due to the risk of teratogenicity. Teriflunomide is also contraindicated in severe hepatic impairment due to reports of hepatotoxicity, hepatic failure, and death.

RX24 Drugs Disclaimer: before buying a Teriflunomide on prescription, consult your healthcare provider. Content on this page is provided for informational purposes only. Any use of this information is at your own risk.

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