Save up -80% on Teriflunomide
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2018 Price of Teriflunomide
* price without discount in nearest pharmacy. Price may vary.
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Teriflunomide volume of distribution
After a single intravenous dose, the volume of distribution is 11 L.
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Teriflunomide
Teriflunomide is the active metabolite of leflunomide, and it acts as an immunomodulatory agent by inhibiting pyrimidine synthesis. It is marketed under the name Aubagio and is indicated for the treatment of multiple sclerosis, specifically relapsing forms. The FDA label states an important warning about the risk of hepatoxicity and teratogenicity for patients using teriflunomide.
Teriflunomide mechanism of action
The exact mechanism by which teriflunomide acts in MS is not known. What is known is that teriflunomide prevents pyrimidine synthesis by inhibiting the mitochondrial enzyme dihydroorotate dehydrogenase, and this may be involved in its immunomodulatory effect in MS.
Dosage forms of Teriflunomide
|Film-coated tablet||Oral use||14 mg|
|Tablet, film coated||oral||14 mg/1|
(Z)-2-Cyano-alpha,alpha,alpha-trifluoro-3-hydroxy-P-crotonotoluidide a 77-1726
Humans and other mammals
Indication of Teriflunomide
Used in the treatment of relapsing forms of multiple sclerosis (MS).
Toxicity of Teriflunomide
Teriflunomide is contraindicated in pregnant women or women of childbearing age due to the risk of teratogenicity. Teriflunomide is also contraindicated in severe hepatic impairment due to reports of hepatotoxicity, hepatic failure, and death.
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