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RX BIN: 015558RX PCN: HTGroup ID: DDN6600Card Holder ID: DDN6600
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2019 Price of Androgel

$196.921 gel pump (88g) 1.62%
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Testosterone volume of distribution

Intracoronary testosterone injections have recently been shown to possess coronary vasodilating effects. The same may be true for intravenous testosterone, but the pharmacokinetic and hemodynamic aspects need exploration before pharmacologic studies can begin. This trial determined the pharmacokinetic and hemodynamic properties of 300 microg of testosterone given intravenously. Degree of testosterone aromatization to 17-beta estradiol after exogenous administration and overall patient tolerability also were evaluated. Eleven elderly men with coronary artery disease participated in the study and were given 300 microg of testosterone intravenously over 10 minutes. Serum blood concentrations of testosterone and 17-beta estradiol were measured at baseline and then periodically. Testosterone serum concentrations were stripped and fit to a two-compartment model for all patients. The volume of distribution (Vdarea) was 80.36 +/- 24.51 L, and the elimination half-life was 55.93 +/- 23.06 minutes. No hemodynamic differences or side effects were noted. The serum concentrations of 17-beta estradiol were significantly increased from baseline beginning 5 minutes after infusion to the end of the study (180 minutes after infusion).

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What is Testosterone

Testosterone is a steroid sex hormone found in both men and women. In men, testosterone is produced primarily by the Leydig (interstitial) cells of the testes when stimulated by luteinizing hormone (LH). It functions to stimulate spermatogenesis, promote physical and functional maturation of spermatozoa, maintain accessory organs of the male reproductive tract, support development of secondary sexual characteristics, stimulate growth and metabolism throughout the body and influence brain development by stimulating sexual behaviors and sexual drive. In women, testosterone is produced by the ovaries (25%), adrenals (25%) and via peripheral conversion from androstenedione (50%). Testerone in women functions to maintain libido and general wellbeing. Testosterone exerts a negative feedback mechanism on pituitary release of LH and follicle-stimulating hormone (FSH). Testosterone may be further converted to dihydrotestosterone or estradiol depending on the tissue.

Testosterone mechanism of action

The effects of testosterone in humans and other vertebrates occur by way of two main mechanisms: by activation of the androgen receptor (directly or as DHT), and by conversion to estradiol and activation of certain estrogen receptors. Free testosterone (T) is transported into the cytoplasm of target tissue cells, where it can bind to the androgen receptor, or can be reduced to 5alpha;-dihydrotestosterone (DHT) by the cytoplasmic enzyme 5alpha;-reductase. DHT binds to the same androgen receptor even more strongly than T, so that its androgenic potency is about 2.5 times that of T. The T-receptor or DHT-receptor complex undergoes a structural change that allows it to move into the cell nucleus and bind directly to specific nucleotide sequences of the chromosomal DNA. The areas of binding are called hormone response elements (HREs), and influence transcriptional activity of certain genes, producing the androgen effects.

Dosage forms of Testosterone

FormRouteStrength
Capsuleoral40 mg
Patchtransdermal12.2 mg
Patchtransdermal2 mg/d

Prescription Generics

false

International Brands

Andriol

Synonyms

17beta-hydroxy-4-androsten-3-one 17beta-Hydroxy-4-androsten-3-one

Manufacturers

Merck Canada Inc

CAS number

58-22-0

UNII

3XMK78S47O

State

solid

Affected organisms

Humans and other mammals

Indication of Testosterone

To be used as hormone replacement or substitution of diminished or absent endogenous testosterone. Use in males: For management of congenital or acquired hypogonadism, hypogonadism associated with HIV infection, and male climacteric (andopause). Use in females: For palliative treatment of androgen-responsive, advanced, inoperable, metastatis (skeletal) carcinoma of the breast in women who are 1-5 years postmenopausal; testosterone esters may be used in combination with estrogens in the management of moderate to severe vasomotor symptoms associated with menopause in women who do not respond to adequately to estrogen therapy alone.

Toxicity of Testosterone

Side effects include amnesia, anxiety, discolored hair, dizziness, dry skin, hirsutism, hostility, impaired urination, paresthesia, penis disorder, peripheral edema, sweating, and vasodilation.

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What is AndroGel?

AndroGel contains testosterone, a natural male hormone necessary for many processes in the body. It works by replacing or supplementing testosterone, which, naturally, is produced in the body. AndroGel is used to treat conditions in men that arise from the lack of natural testosterone.

You should not use AndroGel if you have prostate cancer or male breast cancer. Testosterone can cause birth defects in an unborn baby. A pregnant woman should avoid contact with this medicine or with human skin where the medicine is applied.

Topical testosterone is absorbed through the skin and can cause side effects or symptoms of male features in a child or woman that come into contact with this medicine. Call your doctor if a person who has close contact with you develop extended genitalia, premature pubic hair, increased libido, aggressive behavior, male pattern baldness, excessive body hair growth, increased acne, irregular menstrual periods, or any signs of male characteristics.