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RX BIN: 015558
RX PCN: HT
Group ID: DDN6600
Card Holder ID: DDN6600

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2018 Price of Tetrabenazine

Xenazine 12.5 mg tablet

$37.29

tablet

* price without discount in nearest pharmacy. Price may vary.

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Tetrabenazine volume of distribution

Steady State, IV, in HD or tardive dyskinesia patients: 385L. Tetrabenazine is rapidly distributed to the brain following IV injection. The site with the highest binding is the striatum, while the lowest binding was observed in the cortex.

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What is Tetrabenazine

A drug formerly used as an antipsychotic but now used primarily in the symptomatic treatment of various hyperkinetic disorders. It is a monoamine depletor and used as symptomatic treatment of chorea associated with Huntington’s disease. FDA approved on August 15, 2008.

Tetrabenazine mechanism of action

Tetrabenazine is a reversible human vesicular monoamine transporter type 2 inhibitor (Ki = 100 nM). It acts within the basal ganglia and promotes depletion of monoamine neurotransmitters serotonin, norepinephrine, and dopamine from stores. It also decreases uptake into synaptic vesicles. Dopamine is required for fine motor movement, so the inhibition of its transmission is efficacious for hyperkinetic movement. Tetrabenazine exhibits weak in vitro binding affinity at the dopamine D2 receptor (Ki = 2100 nM).

Dosage forms of Tetrabenazine

FormRouteStrength
Tabletoral25 mg
Tabletoral12.5 mg/1
Tabletoral25 mg/1
Prescription Generics

true

International Brands

Apo-tetrabenazine

Synonyms

1,2,4,6,7,11b-hexahydro-3-Isobutyl-9,10-dimethoxy-2H-benzo[a]quinolizin-2-one 2-oxo-3-Isobutyl-9,10-dimethoxy-1,2,3,4,6,7-hexahydro-11bh-benzo[a]quinolizine

Manufacturers

Apotex Inc

CAS number

58-46-8

UNII

Z9O08YRN8O

State

solid

Affected organisms

Humans and other mammals

Indication of Tetrabenazine

Treatment of hyperkinetic movement disorders like chorea in Huntington’s disease, hemiballismus, senile chorea, Tourette syndrome and other tic disorders, and tardive dyskinesia

Toxicity of Tetrabenazine

Dose-limiting adverse effects are sedation, parkinsonism, akathsia, and depression. LD50 oral, mouse: 550 mg/kg

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